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. 2023 Jan;58(1):197-205.
doi: 10.1002/ppul.26180. Epub 2022 Nov 2.

Variability of clinically measured lung clearance index in children with cystic fibrosis

Bettina S Frauchiger  1 , Kathryn A Ramsey  1 , Jakob Usemann  2   3 , Elisabeth Kieninger  1 , Carmen Casaulta  1 , Daniel Sirtes  1 , Sophie Yammine  1 , Ben Spycher  4 , Alexander Moeller  2 , Philipp Latzin  1
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Free article

Variability of clinically measured lung clearance index in children with cystic fibrosis

Bettina S Frauchiger et al. Pediatr Pulmonol. 2023 Jan.
Free article

Abstract

Rationale: The lung clearance index (LCI) is increasingly being used in the clinical surveillance of patients with cystic fibrosis (CF). However, there are limited data on long-term variability and physiologically relevant changes in LCI during routine clinical surveillance.

Objectives: To evaluate the long-term variability of LCI and propose a threshold for a physiologically relevant change.

Methods: In children aged 4-18 years with CF, LCI was measured every 3 months as part of routine clinical surveillance during 2011-2020 in two centers. The variability of LCI during periods of clinical stability was assessed using mixed-effects models and was used to identify thresholds for physiologically relevant changes.

Results: Repeated LCI measurements of acceptable quality (N = 858) were available in 100 patients with CF; for 74 patients, 399 visits at clinical stability were available. The variability of repeated LCI measurements over time expressed as the coefficient of variation (CV%) was 7.4%. The upper limit of normal (ULN) for relative changes in LCI between visits was 19%.

Conclusion: We report the variability of LCI in children and adolescents with CF during routine clinical surveillance. According to our data, a change in LCI beyond 19% may be considered physiologically relevant. These findings will help guide clinical decisions according to LCI changes.

Keywords: children; cystic fibrosis; lung.

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References

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