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Case Reports
. 2023 Jan 1;48(1):e33-e34.
doi: 10.1097/RLU.0000000000004443. Epub 2022 Oct 17.

A "Leopard Man" Aspect on 18 F-FDG PET/CT Revealing a VEXAS Syndrome

Alexandre Fagart  1 , Thomas Quemeneur  2 , Guillaume Collet  1 , Franck Demailly  1 , Clementine Rousselin  2
Affiliations
Case Reports

A "Leopard Man" Aspect on 18 F-FDG PET/CT Revealing a VEXAS Syndrome

Alexandre Fagart et al. Clin Nucl Med. .

Abstract

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an adult-onset autoinflammatory disease caused by somatic UBA1 mutations first described in 2020. Most of these patients met clinical criteria for an inflammatory syndrome (relapsing polychondritis, Sweet syndrome, polyarteritis nodosa, or giant-cell arteritis) or a hematologic condition (myelodysplastic syndrome or multiple myeloma) or both. We described here an FDG PET/CT "leopard man" appearance, with abnormal marrow recruitment the findings, in a 70-year-old man diagnosed with a VEXAS syndrome.

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Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

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