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. 2022 Jan-Dec;14(1):2133666.
doi: 10.1080/19420862.2022.2133666.

Pandemic's silver lining

Fortunato Ferrara  1 , Sara D'Angelo  1 , M Frank Erasmus  1 , André A Teixeira  2 , Camila Leal-Lopes  2 , Laura P Spector  1 , Tom Pohl  1 , Adeline Fanni  1 , Simon Cocklin  1 , Andrew R M Bradbury  1
Affiliations

Pandemic's silver lining

Fortunato Ferrara et al. MAbs. 2022 Jan-Dec.

Abstract

The intense international focus on the COVID-19 pandemic has provided a unique opportunity to use a wide array of novel tools to carry out scientific studies on the SARS-CoV-2 virus. The value of these comparative studies extends far beyond their consequences for SARS-CoV-2, providing broad implications for health-related science. Here we specifically discuss the impacts of these comparisons on advances in vaccines, the analysis of host humoral immunity, and antibody discovery. As an extension, we also discuss potential synergies between these areas.Abbreviations: CoVIC: The Coronavirus Immunotherapeutic Consortium; EUA: Emergency Use Authorization.

Keywords: SARS-CoV-2; monoclonal antibodies; vaccines.

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Conflict of interest statement

AART and CLL received financing from Specifica Inc. SD, MFE, FF, LPS, LN, EM, TM, ADA, KP, and ARMB are employed by Specifica Inc.

Figures

The figure shows that 22 neutralizing antibodies with different HCDR3 sequences nevertheless bind to the same epitope on the Receptor Binding Domain of the SARS-CoV-2 spike protein, and that their structures overlap with each other, and also bind at the same site bound by ACE2.
Figure 1.
a) A cartoon representation of 22 antibodies binding to the “neck” of SARS-CoV-2 RBD (salmon), with b) showing ACE-2 (turquoise) binding at the same site. c) The CDRH3 sequences represented across the 22 RBD ‘neck’-binding antibodies. Lenient VH-clonotypes are separated with solid lines, with the cluster representative highlighted in bold font (derived from Robinson et al.).
See this image and copyright information in PMC

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