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. 2022 Dec;21(12):863-864.
doi: 10.1038/d41573-022-00170-7.

The NCATS Assay Guidance Manual programme: advancing the practice and rigour of preclinical translation

Sarine Markossian, Kyle R Brimacombe, G Sitta Sittampalam, Abigail Grossman, Nathan P Coussens, James Inglese, Douglas S Auld, William Chin, Christopher P Austin, Matthew D Hall

The NCATS Assay Guidance Manual programme: advancing the practice and rigour of preclinical translation

Sarine Markossian et al. Nat Rev Drug Discov. 2022 Dec.

Abstract

The Assay Guidance Manual programme, a translational science education and training initiative at the US National Center for Advancing Translational Sciences (NCATS), aims to help bridge the gap between research discoveries and the delivery of new therapies by creating and disseminating experimental protocols and standards for rigour in preclinical translational research.

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References

    1. Markossian S. et al. (eds) Assay Guidance Manual (Eli Lilly & Company and the National Center for Advancing Translational Sciences, 2004). - PubMed
    1. Coussens NP. et al. Assay Guidance Manual: quantitative biology and pharmacology in preclinical drug discovery. Clin. Transl. Sci. 11, 461–470 (2018). - PMC - PubMed
    1. Austin CP. Opportunities and challenges in translational science. Clin. Transl. Sci. 14, 1629–1647 (2021). - PMC - PubMed
    1. National Academies of Sciences, Engineering, and Medicine. Reproducibility and Replicability in Science. (The National Academies Press, 2019). doi: 10.17226/25303. - DOI - PubMed
    1. Freedman LP., Cockburn IM. & Simcoe TS. The economics of reproducibility in preclinical research. PLOS Biol. 13, e1002165 (2015). - PMC - PubMed

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