Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023:277:299-337.
doi: 10.1007/164_2022_609.

Chemotherapy-Induced Peripheral Neuropathy

Ciao-Sin Chen  1 , Daniel L Hertz  2
Affiliations

Chemotherapy-Induced Peripheral Neuropathy

Ciao-Sin Chen et al. Handb Exp Pharmacol. 2023.

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of many common anti-cancer agents that can lead to dose reduction or treatment discontinuation, which decrease chemotherapy efficacy. Long-term CIPN can interfere with activities of daily living and diminish the quality of life. The mechanism of CIPN is not yet fully understood, and biomarkers are needed to identify patients at high risk and potential treatment targets. Metabolomics can capture the complex behavioral and pathophysiological processes involved in CIPN. This chapter is to review the CIPN metabolomics studies to find metabolic pathways potentially involved in CIPN. These potential CIPN metabolites are then investigated to determine whether there is evidence from studies of other neuropathy etiologies such as diabetic neuropathy and Leber hereditary optic neuropathy to support the importance of these pathways in peripheral neuropathy. Six potential biomarkers and their putative mechanisms in peripheral neuropathy were reviewed. Among these biomarkers, histidine and phenylalanine have clear roles in neurotransmission or neuroinflammation in peripheral neuropathy. Further research is needed to discover and validate CIPN metabolomics biomarkers in large clinical studies.

Keywords: Chemotherapy; Histidine; Metabolomics; Peripheral neuropathy; Phenylalanine.

PubMed Disclaimer

References

    1. Albrahim T (2020) The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies. Neurosciences 25:4–17. https://doi.org/10.17712/nsj.2020.1.20190037 - DOI - PubMed - PMC
    1. Altorf-van der Kuil W, Brink EJ, Boetje M, Siebelink E, Bijlsma S, Engberink MF, van’t Veer P, Tomé D, Bakker SJ, van Baak MA, Geleijnse JM (2013) Identification of biomarkers for intake of protein from meat, dairy products and grains: a controlled dietary intervention study. Br J Nutr 110:810–822. https://doi.org/10.1017/s0007114512005788 - DOI - PubMed
    1. Argyriou AA, Iconomou G, Kalofonos HP (2008) Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature. Blood 112:1593–1599. https://doi.org/10.1182/blood-2008-04-149385 - DOI - PubMed
    1. Azevedo MI, Pereira AF, Nogueira RB, Rolim FE, Brito GA, Wong DV, Lima-Júnior RC, de Albuquerque RR, Vale ML (2013) The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy. Mol Pain 9:53. https://doi.org/10.1186/1744-8069-9-53 - DOI - PubMed - PMC
    1. Backshall A, Sharma R, Clarke SJ, Keun HC (2011) Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine. Clin Cancer Res 17:3019–3028. https://doi.org/10.1158/1078-0432.Ccr-10-2474 - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources