A case of death of patient with ovarian fibroma combined with Meigs Syndrome and literature review

Abstract

Ovarian fibroma is the most common benign pure stromal tumor. It has no specific clinical manifestation, most of which are pelvic or adnexal masses. 10-15% of cases with hydrothorax or ascites, after tumor resection, hydrothorax and ascites disappear, known as Meigs Syndrome. The elevated level of CA125 in a few patients was easily misdiagnosed as ovarian malignant tumor. A case of bilateral Ovarian fibroma associated with Meigs Syndrome is reported and the literature is reviewed in order to improve the understanding of the changes and avoid misdiagnosis.

Keywords: Meigs Syndrome; Ovarian fibroma.

Fig. 1

A and B, CT coronal images through the 10th thoracic vertebrae and the pelvis demonstrate there were multiple irregular cystic and solid masses in bilateral adnexa (White small arrow). A large amount of effusion (white big arrowhead) is present within the bilateral thoracic cavity and pelvic and abdominal cavity. the uterus (circle 1), the bladder (circle 2)

Fig. 2

Laparoscopic Intraoperative photograph, can be found bilateral ovarian fibroma (black cross) and ascites (black arrow)

Fig. 3

A Histology: showed a large number of spindle cells or ovoid cells, Tumor cell nucleus is long fusiform. There is an obvious edema between cells (400×). B Immunohistochemistry: α-inhibin weakly positive (100×). C Immunohistochemistry: Vimentin positive (100×). D Immunohistochemistry: Reticular fiber positive (400×)