Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Oct 14;101(41):e31042.
doi: 10.1097/MD.0000000000031042.

Graves' hyperthyroidism induced pancytopenia, epilepsia and muscle weakness: A case report

Bao Fu  1 , Dinghong He  2 , Zhengguang Geng  1 , Xiaoyun Fu  1
Affiliations
Case Reports

Graves' hyperthyroidism induced pancytopenia, epilepsia and muscle weakness: A case report

Bao Fu et al. Medicine (Baltimore). .

Abstract

Rationale: Pancytopenia and epilepsia are rare complications of Graves' disease (GD). Muscle weakness is a physical sign of GD. It is extremely rare for GD patients to present 3 symptoms at the same time.

Patient concerns: A 35-year-old female was admitted to hospital for dizziness for 1 day. The results of laboratory examination on admission showed pancytopenia and hypothyroidism. Her clinical manifestations include pancytopenia, epilepsy, and muscle weakness.

Diagnosis: Graves' hyperthyroidism.

Interventions: She received endotracheal intubation, ventilator, antithyroid drugs, and hormone therapy.

Outcome: The patient was discharged after treatment.

Lesson: Severe complications caused by GD are rare and require antithyroid therapy. Although glucocorticoid is not recommended by the guidelines, it can effectively improve thrombocytopenia.

PubMed Disclaimer

Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
The changes of white blood cell count (A), hemoglobin (B) and platelet count (C). The treatment course of the patients (D).
See this image and copyright information in PMC

References

    1. Smith TJ, Hegedus L. Graves’ disease. N Engl J Med. [Review]. 2016;375:1552–1565. - PubMed
    1. Nordyke RA, Gilbert FI, Jr, Harada AS. Graves’ disease. Influence of age on clinical findings. Arch Intern Med. [Research Support, Non-U.S. Gov’t]. 1988;148:626–31. - PubMed
    1. Scappaticcio L, Bellastella G, Maiorino MI, et al. . Graves’ hyperthyroidism-related pancytopenia: a case report with literature review. Hormones (Athens). [Review]. 2021;20:93–100. - PubMed
    1. Pincet L, Gorostidi F. Graves disease causing pancytopenia: case report and literature review. Clin Med Insights Case Rep. [Case Reports]. 2018;11:1179547618781090. - PMC - PubMed
    1. Kyritsi EMA, Yiakoumis X, Pangalis GA, et al. . High frequency of thyroid disorders in patients presenting with neutropenia to an outpatient hematology clinic STROBE-compliant article. Medicine. [Observational Study]. 2015;94:e886. - PMC - PubMed

Publication types