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Editorial
. 2022 Sep 30:13:1034689.
doi: 10.3389/fimmu.2022.1034689. eCollection 2022.

Editorial: DNA repair and immune response

Paulo José Basso  1 , Clarissa Ribeiro Reily Rocha  2 , Erik A L Biessen  3 , Ingrid Van der Pluijm  4 , Carlos Frederico Martins Menck  5 , Niels Olsen Saraiva Câmara  1   6
Affiliations
Editorial

Editorial: DNA repair and immune response

Paulo José Basso et al. Front Immunol. .
No abstract available

Keywords: DNA damage response; DNA lesions; cancer; immune cells; inflammation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Relationship between inflammatory response and DNA damage in health and disease. (A) DNA damage response and immunity are closely related systems. They work together to deal with several negative stressors as well as to perform some physiological processes that require deliberate DNA breaks and rearrangement (e.g., lymphocyte receptor assembling, CSR, SHM), yielding a diverse set of immune receptors and antibodies capable of recognizing a broad range of antigens. (B) Chronic low-grade inflammation induces persistent DNA damage, and vice-versa, leading to cancer development. Current cancer treatment options envisage approaches targeting inflammatory or DNA-damaging agents separately. However, combined therapies have gained special attention as a potential strategy to improve the efficacy of cancer treatment. Here, we positioned the respective study from the manuscript collection closely to its main topic with the names of the authors highlighted in yellow, featuring the importance of the study’s contribution to the field. CSR, class switch recombination; DDR, DNA damage response; ICIs, immune checkpoint inhibitors; SHM, somatic hypermutation; UV, ultraviolet (radiation).
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References

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