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. 2022 Dec;63(14):3351-3361.
doi: 10.1080/10428194.2022.2131419. Epub 2022 Oct 18.

A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Andres V Ardisson Korat  1 , Yu-Han Chiu  2   3 , Kimberly A Bertrand  4 , Shumin Zhang  5   6 , Mara M Epstein  7 , Bernard A Rosner  1   8 , Stephanie Chiuve  3   9 , Hannia Campos  3   10 , Edward L Giovannucci  2   3 , Jorge E Chavarro  1   2   3 , Brenda M Birmann  1
Affiliations

A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Andres V Ardisson Korat et al. Leuk Lymphoma. 2022 Dec.

Abstract

Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses' Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03-1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23-4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.

Keywords: Red blood cell membrane fatty acids; epidemiology; etiology; non-Hodgkin lymphoma; polyunsaturated fatty acids; prospective.

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Conflict of interest statement

Disclosure statement: SC is presently an employee at AbbVie, in which capacity she receives stock/stock options; SZ is presently an employee and holds restricted share units of Johnson & Johnson; neither SC nor SZ had competing interests or conflicts at the time the project was designed, funded and initiated. The remaining authors declare no potential competing interests or conflicts of interest.

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