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. 2022 Nov 4;87(21):13891-13894.
doi: 10.1021/acs.joc.2c01597. Epub 2022 Oct 18.

Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum's Acids

Tarn C Johnson  1 , Stephen P Marsden  1
Affiliations

Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum's Acids

Tarn C Johnson et al. J Org Chem. .

Abstract

A convenient and simple three-component synthesis of substituted pyridylacetic acid derivatives is reported. The approach centers on the dual reactivity of Meldrum's acid derivatives, initially as nucleophiles to perform substitution on activated pyridine-N-oxides, then as electrophiles with a range of nucleophiles to trigger ring-opening and decarboxylation.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Representative pyridylacetic acid derivatives and proposed synthetic approach.
Scheme 1
Scheme 1. Proposed Synthetic Approach
See this image and copyright information in PMC

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