Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 18;13(1):6152.
doi: 10.1038/s41467-022-33825-5.

Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial

Olli P O Nevalainen  1   2   3   4 , Saana Horstia  1 , Sanna Laakkonen  1 , Jarno Rutanen  2   5 , Jussi M J Mustonen  6 , Ilkka E J Kalliala  7   8 , Hanna Ansakorpi  9 , Hanna-Riikka Kreivi  10 , Pauliina Kuutti  1 , Juuso Paajanen  10 , Seppo Parkkila  11 , Erja-Leena Paukkeri  5 , Markus Perola  12   13 , Negar Pourjamal  1 , Andreas Renner  10   14 , Tuomas Rosberg  15 , Taija Rutanen  16 , Joni Savolainen  16 ; Solidarity Finland Investigators; Jari K Haukka  17   18 , Gordon H Guyatt  19   20 , Kari A O Tikkinen  21   22
Collaborators, Affiliations

Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial

Olli P O Nevalainen et al. Nat Commun. .

Abstract

We report the first long-term follow-up of a randomized trial (NCT04978259) addressing the effects of remdesivir on recovery (primary outcome) and other patient-important outcomes one year after hospitalization resulting from COVID-19. Of the 208 patients recruited from 11 Finnish hospitals, 198 survived, of whom 181 (92%) completed follow-up. At one year, self-reported recovery occurred in 85% in remdesivir and 86% in standard of care (SoC) (RR 0.94, 95% CI 0.47-1.90). We infer no convincing difference between remdesivir and SoC in quality of life or symptom outcomes (p > 0.05). Of the 21 potential long-COVID symptoms, patients reported moderate/major bother from fatigue (26%), joint pain (22%), and problems with memory (19%) and attention/concentration (18%). In conclusion, after a one-year follow-up of hospitalized patients, one in six reported they had not recovered well from COVID-19. Our results provide no convincing evidence of remdesivir benefit, but wide confidence intervals included possible benefit and harm.

PubMed Disclaimer

Conflict of interest statement

H.-R.K. served on advisory boards for Roche, and Pfizer outside the submitted work. T.R. reported honoraria from AstraZeneca, Boehringer-Ingelheim, and GSK outside the submitted work; and reported having support for attending meetings from MSD, Roche, and Orion outside the submitted work. The remaining authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Study flow chart.
Fig. 2
Fig. 2. Bother from potential long-COVID symptoms at 1 year from COVID-19 hospitalization between the standard of care and standard of care plus remdesivir groups.
RDV stands for remdesivir plus standard of care group, and SoC for standard of care group.
See this image and copyright information in PMC

References

    1. Crook H, Raza S, Nowell J, Young M, Edison P. Long covid-mechanisms, risk factors, and management. BMJ. 2021;374:n1648. doi: 10.1136/bmj.n1648. - DOI - PubMed
    1. Nalbandian A, et al. Post-acute COVID-19 syndrome. Nat. Med. 2021;27:601–615. doi: 10.1038/s41591-021-01283-z. - DOI - PMC - PubMed
    1. World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. World Health Organization https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_cond... (2022).
    1. Munblit D, et al. Long COVID: aiming for a consensus. Lancet Respir. Med. 2022;S2213-2600:00135–00137. - PMC - PubMed
    1. Groff D, et al. Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review. JAMA Netw. Open. 2021;4:e2128568. doi: 10.1001/jamanetworkopen.2021.28568. - DOI - PMC - PubMed

Publication types