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Review
. 2022 Dec;11(4):305-335.
doi: 10.1007/s13679-022-00490-0. Epub 2022 Oct 18.

The Role of Nutrition on Meta-inflammation: Insights and Potential Targets in Communicable and Chronic Disease Management

Omar Ramos-Lopez  1 , Diego Martinez-Urbistondo  2 , Juan A Vargas-Nuñez  3   4 , J Alfredo Martinez  5   6   7
Affiliations
Review

The Role of Nutrition on Meta-inflammation: Insights and Potential Targets in Communicable and Chronic Disease Management

Omar Ramos-Lopez et al. Curr Obes Rep. 2022 Dec.

Abstract

Purpose of review: Chronic low-grade inflammation may contribute to the onset and progression of communicable and chronic diseases. This review examined the effects and eventual mediation roles of different nutritional factors on inflammation.

Recent findings: Potential nutritional compounds influencing inflammation processes include macro and micronutrients, bioactive molecules (polyphenols), specific food components, and culinary ingredients as well as standardized dietary patterns, eating habits, and chrononutrition features. Therefore, research in this field is still required, taking into account critical aspects of heterogeneity including type of population, minimum and maximum intakes and adverse effects, cooking methods, physiopathological status, and times of intervention. Moreover, the integrative analysis of traditional variables (age, sex, metabolic profile, clinical history, body phenotype, habitual dietary intake, physical activity levels, and lifestyle) together with individualized issues (genetic background, epigenetic signatures, microbiota composition, gene expression profiles, and metabolomic fingerprints) may contribute to the knowledge and prescription of more personalized treatments aimed to improving the precision medical management of inflammation as well as the design of anti-inflammatory diets in chronic and communicable diseases.

Keywords: Anti-inflammatory diets; Bioactive compounds; Disease; Inflammation; Nutrition; Personalized nutrition.

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Conflict of interest statement

All authors reported no conflict of interest.

Figures

Fig. 1
Fig. 1
Nutritional factors associated with inflammatory outcomes in humans. DASH, Dietary Approaches to Stop Hypertension; EGCG, epigallocatechin-3-gallate; Med-diet, Mediterranean diet; MUFA, monounsaturated fatty acids; PREDIMED, Prevención con Dieta Mediterránea; PUFA, polyunsaturated fatty acids; SEAD, Southern European Atlantic Diet; SFA, saturated fatty acids; TFA, trans fatty acids; TMexD, traditional Mexican diet
Fig. 2
Fig. 2
Precision information for the prescription of personalized anti-inflammatory nutritional strategies
See this image and copyright information in PMC

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