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Review
. 2022 Dec;67(4):1463-1470.
doi: 10.1007/s11686-022-00621-6. Epub 2022 Oct 19.

Manipulation by Plasmodium Parasites of Anopheles Mosquito Behavior and Human Odors

Tristan Sanford  1 , Dave Shutler  2
Affiliations
Review

Manipulation by Plasmodium Parasites of Anopheles Mosquito Behavior and Human Odors

Tristan Sanford et al. Acta Parasitol. 2022 Dec.

Abstract

Purpose: The phenomenon of parasites manipulating host phenotypes is well documented; the best-known examples are manipulations of host behavior. More recently, there has been interest in whether parasites can manipulate host odor phenotypes to enhance their attractiveness to vectors. We review here evidence that Plasmodium-infected mosquitoes have enhanced attraction to human hosts, especially when the parasite is sufficiently developed to be transmissible. We also review evidence suggesting that malaria-infected host odors elicit greater mosquito attraction compared to uninfected controls.

Methods: We reviewed and summarized the relevant literature.

Results: Though evidence is mounting that supports both premises we reviewed, there are several confounds that complicate interpretation. These include differences in Plasmodium and mosquito species studied, stage of infection tested, age of human participants in trials, and methods used to quantify volatiles. In addition, a key requirement to support the hypothesis of manipulation by parasites is that costs of manipulation be identified, and ideally, quantified.

Conclusions: Substantial progress has been made to unlock the importance of odor for enhancing transmission of Plasmodium. However, there needs to be more replication using similar methods to better define the odor parameters involved in this enhancement.

Keywords: Malaria; Manipulation of host odor; Transmissible stages; Volatile organic compounds.

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References

    1. Moore J (2002) Parasites and the behavior of animals. Oxford University Press
    1. Hudson PJ, Dobson AP, Newborn D (1992) Do parasites make prey vulnerable to predation? Red grouse and parasites. J Anim Ecol 61:681–692. https://doi.org/10.2307/5623 - DOI
    1. Busula AO, Bousema T, Mweresa CK, Masiga D, Logan JG, Sauerwein RW et al (2017) Gametocytemia and attractiveness of Plasmodium falciparum–infected Kenyan children to Anopheles gambiae mosquitoes. J Infect Dis 216:216–291. https://doi.org/10.1093/infdis/jix214 - DOI
    1. Bush AO, Lafferty KD, Lotz JM, Shostak AW (1997) Parasitology meets ecology on its own terms: Margolis et al. revisited. J Parasitol 83:575–583. https://doi.org/10.2307/3284227 - DOI - PubMed
    1. Roberts LS, Janovy J Jr (2005) Foundations of parasitology, 7th edn. McGraw-Hill, New York, NY

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