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Comment
. 2022 Nov 7;221(11):e202210014.
doi: 10.1083/jcb.202210014. Epub 2022 Oct 19.

A second chance at yeast early endosomes

Allyson F O'Donnell  1
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Comment

A second chance at yeast early endosomes

Allyson F O'Donnell. J Cell Biol. .

Abstract

Post-endocytic recycling in yeast has been posited to transit solely through the Golgi, raising the possibility that yeast lack early endosomes. In this issue, Laidlaw and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109137) describe a yeast endosomal recycling pathway that gives proteins a second chance to return to the plasma membrane.

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Figures

Figure 1.
Figure 1.
Ist1 regulates recycling from EEs in yeast. Methionine induces Mup1 endocytosis, but rapid removal of this signal captures Mup1 in Vps4-positive EEs. Ist1 is required for Mup1 recycling from EEs to the PM. Snc1 recycles through a different route, using the Sec7-positive TGN. Cdc48-Npl4 are needed for Ist1-mediated recycling and may control Ist1 depolymerization. Vps4-positive LEs, Ivy1-positive SEs, and Sec7-positive TGN are all distinct from the Ist1-marked EEs.
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References

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