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Review
. 2023 Jan 27:74:107-116.
doi: 10.1146/annurev-med-043021-032007. Epub 2022 Oct 19.

Gender-Affirming Care of Transgender and Gender-Diverse Youth: Current Concepts

Janet Y Lee  1   2   3 , Stephen M Rosenthal  1
Affiliations
Review

Gender-Affirming Care of Transgender and Gender-Diverse Youth: Current Concepts

Janet Y Lee et al. Annu Rev Med. .

Abstract

Increasing numbers of transgender and gender-diverse (TGD) youth, from early puberty through late adolescence, are seeking medical services to bring their physical sex characteristics into alignment with their gender identity-their inner sense of self as male or female or elsewhere on the gender spectrum. Numerous studies, primarily of short- and medium-term duration (up to 6 years), demonstrate the clearly beneficial-even lifesaving-mental health impact of gender-affirming medical care in TGD youth. However, there are significant gaps in knowledge and challenges to such care. Long-term safety and efficacy studies are needed to optimize medical care for TGD youth.

Keywords: gender-affirming hormone treatment; gender-diverse youth; gonadotropin-releasing hormone agonists; pubertal blockers; transgender.

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References

    1. Herman JL, Flores AR, Brown TNT, Wilson BDM, Conron KJ. 2017. Age of Individuals Who Identify as Transgender in the United States, The Williams Institute: UCLA School of Law, Los Angeles, CA
    1. Johns MM, Lowry R, Andrzejewski J, Barrios LC, Demissie Z, et al. 2019. Transgender Identity and Experiences of Violence Victimization, Substance Use, Suicide Risk, and Sexual Risk Behaviors Among High School Students - 19 States and Large Urban School Districts, 2017. MMWR Morb Mortal Wkly Rep 68:67–71 - PMC - PubMed
    1. Rider GN, McMorris BJ, Gower AL, Coleman E, Eisenberg ME. 2018. Health and Care Utilization of Transgender and Gender Nonconforming Youth: A Population-Based Study. Pediatrics 141 - PMC - PubMed
    1. Wiepjes CM, Nota NM, de Blok CJM, Klaver M, de Vries ALC, et al. 2018. The Amsterdam Cohort of Gender Dysphoria Study (1972–2015): Trends in Prevalence, Treatment, and Regrets. J Sex Med 15:582–90 - PubMed
    1. Arnoldussen M, Steensma TD, Popma A, van der Miesen AIR, Twisk JWR, de Vries ALC. 2020. Re-evaluation of the Dutch approach: are recently referred transgender youth different compared to earlier referrals? Eur Child Adolesc Psychiatry 29:803–11 - PMC - PubMed