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Comment
. 2022 Oct 18;3(10):100789.
doi: 10.1016/j.xcrm.2022.100789.

Reducing misclassification bias in severe malaria research

Matthew M Ippolito  1 , Matthew L Robinson  2
Affiliations
Comment

Reducing misclassification bias in severe malaria research

Matthew M Ippolito et al. Cell Rep Med. .

Abstract

By incorporating platelets and PfHRP2 into standard case definitions of severe falciparum malaria, Watson et al.1 increased diagnostic specificity to 93%. The approach trades off sensitivity and might introduce a selection bias but offers a helpful way to handle misclassification.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Hidden Biomass of Intact Malaria Parasites in the Human Spleen.
    Kho S, Qotrunnada L, Leonardo L, Andries B, Wardani PAI, Fricot A, Henry B, Hardy D, Margyaningsih NI, Apriyanti D, Puspitasari AM, Prayoga P, Trianty L, Kenangalem E, Chretien F, Safeukui I, Del Portillo HA, Fernandez-Becerra C, Meibalan E, Marti M, Price RN, Woodberry T, Ndour PA, Russell BM, Yeo TW, Minigo G, Noviyanti R, Poespoprodjo JR, Siregar NC, Buffet PA, Anstey NM. Kho S, et al. N Engl J Med. 2021 May 27;384(21):2067-2069. doi: 10.1056/NEJMc2023884. N Engl J Med. 2021. PMID: 34042394 No abstract available.
  • Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations.
    Watson JA, Uyoga S, Wanjiku P, Makale J, Nyutu GM, Mturi N, George EC, Woodrow CJ, Day NPJ, Bejon P, Opoka RO, Dondorp AM, John CC, Maitland K, Williams TN, White NJ. Watson JA, et al. Sci Transl Med. 2022 Jul 20;14(654):eabn5040. doi: 10.1126/scitranslmed.abn5040. Epub 2022 Jul 20. Sci Transl Med. 2022. PMID: 35857826 Free PMC article.

References

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