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. 2024 May;41(S 01):e648-e653.
doi: 10.1055/s-0042-1756641. Epub 2022 Oct 19.

Prevalence of Maternal Cytomegalovirus Antibodies and Neonatal Congenital Cytomegalovirus at Less than 34 Weeks of Gestation: A Prospective Study

Shilpa U Kalane  1 , Lavannya Raste  2 , Sampada Patwardhan  3 , Digna A Beasley  4 , Uday P Devaskar  5
Affiliations

Prevalence of Maternal Cytomegalovirus Antibodies and Neonatal Congenital Cytomegalovirus at Less than 34 Weeks of Gestation: A Prospective Study

Shilpa U Kalane et al. Am J Perinatol. 2024 May.

Abstract

Objective: Congenital cytomegalovirus (cCMV) acquired postnatally can lead to hearing loss and adverse central nervous system (CNS) function, especially in the preterm neonate. We prospectively determined the prevalence of maternal serum CMV-immunoglobulin (IgG) and the incidence of cCMV at <34 weeks of gestation.

Study design: Study was conducted in the United States and India. Maternal blood was collected within 5 days after delivery. CMV-IgG antibodies were quantitated by an immunoassay. Baby's urine at birth was tested for CMV-DNA by the polymerase chain reaction.

Results: In total, 65 women and 74 neonates were studied. In the United States, 6 out of 21 (76%), while in India, 42 out of 44 (96%) mothers were seropositive (combined 89%). In the United States, none of the neonates had CMV in the urine, while in India 4 out of 52 (7.7%) were positive (combined 5.4%) CONCLUSION: Mother's blood and baby's urine should be tested for serum CMV-IgG antibodies and CMV-DNA at delivery at <34-weeks of gestational age. Targeted screening will help in making an early diagnosis of cCMV, initiate therapy, and detect and treat early CNS problems including hearing loss.

Key points: · Maternal serum CMV screening after premature delivery at less than 34 weeks of gestation.. · Neonatal urine CMV screening at less than 34 weeks of gestation.. · Prematurity: importance of CMV during premature labor and delivery at less than 34 weeks..

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Conflict of interest statement

None declared.

References

    1. Schleiss M R. Breast milk acquired cytomegalovirus in premature infants: uncertain consequences and unsolved biological questions. JAMA Pediatr. 2020;174(02):121–123. - PubMed
    1. Bardanzellu F, Fanos V, Reali A. Human breast milk-acquired cytomegalovirus infection: certainties, doubts and perspectives. Curr Pediatr Rev. 2019;15(01):30–41. - PMC - PubMed
    1. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network . Hughes B L, Clifton R G, Rouse D J et al.A trial of hyperimmune globulin to prevent congenital cytomegalovirus infection. N Engl J Med. 2021;385(05):436–444. - PMC - PubMed
    1. Harrison G J. 7th ed. Philadelphia, PA: Elsevier Saunders; 2014. Cytomegalovirus; p. 1969.
    1. Demmler-Harrison G J. Congenital cytomegalovirus infection: the elephant in our living room. JAMA Pediatr. 2016;170(12):1142–1144. - PubMed

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