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. 2022 Oct 19;12(1):17493.
doi: 10.1038/s41598-022-22301-1.

Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study

Tomoyo Yasukawa  1 , Akiko Hanyuda  2   3 , Kazumasa Yamagishi  4   5 , Kenya Yuki  1 , Miki Uchino  1 , Yoko Ozawa  1   6 , Mariko Sasaki  1   7   8 , Kazuo Tsubota  9 , Norie Sawada  10 , Kazuno Negishi  1 , Shoichiro Tsugane  10   11 , Hiroyasu Iso  12
Affiliations

Relationship between blood pressure and intraocular pressure in the JPHC-NEXT eye study

Tomoyo Yasukawa et al. Sci Rep. .

Abstract

Although a positive link between hypertension and intraocular pressure (IOP) has been suggested, the individual effects of systolic and diastolic blood pressure (SBP and DBP, respectively) on IOP remain unclear, particularly among Japanese populations. Here, we conducted a large-scale, cross-sectional study to determine individual and combined effects of SBP/DBP and hypertension on IOP. In total, 6783 Japanese people aged over 40 years underwent systemic and ophthalmological examinations, including measurements of blood pressure and IOP, conducted using non-contact tonometers. After adjusting for a priori known confounding factors, SBP and DBP levels were found to be positively correlated with IOP levels. The multivariable-adjusted odds ratio when comparing the hypertensive and normotensive groups for the prevalence of ocular hypertension was 1.88 (95% confidence interval, 1.14-3.08). When analysing the combined effects of SBP and DBP on ocular hypertension, SBP elevation had a greater effect on ocular hypertension than DBP increase. In conclusion, SBP and DBP levels and the prevalence of systemic hypertension were found to be positively associated with IOP levels and the prevalence of ocular hypertension in an ophthalmologically healthy Japanese population. Our findings suggest that systemic blood pressure control may be key for controlling IOP.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Distribution of intraocular pressure according to hypertensive status.
See this image and copyright information in PMC

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