Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun 28;3(3):172-178.
doi: 10.36628/ijhf.2021.0006. eCollection 2021 Jul.

Incidence, Cause of Death, and Survival of Amyloidosis in Korea: A Retrospective Population-Based Study

Shin Yi Jang  1 , Darae Kim  1 , Jin-Oh Choi  1 , Eun-Seok Jeon  1
Affiliations

Incidence, Cause of Death, and Survival of Amyloidosis in Korea: A Retrospective Population-Based Study

Shin Yi Jang et al. Int J Heart Fail. .

Abstract

Background and objectives: We sought to assess incidence, cause of death, and survival for amyloidosis. We acquired amyloidosis data from the National Health Insurance Service in Korea from 2006 through 2017 (n=2,233; male 53.5%).

Methods: We calculated the age-standardized incidence rate, analyzed the survival rate (SR) using the Kaplan-Meier method, and analyzed the death risk using Cox proportional hazards methods.

Results: The mean age was 57.0±16.7 years in males and 56.8±15.6 years in females (p=0.795). The proportion of death was 34.7%. The causes of death were endocrine, nutritional, and metabolic diseases (33.9%), malignant neoplasm (20.8%), and diseases of the circulatory system (9.68%). The overall age-standardized incidence rate was 0.47 persons per 100,000 persons in 2017. Overall, the 10-year SR for amyloidosis was 57.7%. Adjusted hazard ratios were 9.16 among 40s', 16.1 among 50s', 30.3 among 60s', 48.7 among 70s', 80.1 among people 80 years or older, and 1.21 in the medium-level socioeconomic position group.

Conclusions: The age-standardized incidence rate of amyloidosis was about 0.5 persons per 100,000 persons in 2017. The 10-year SR of amyloidosis was about 58%. The most common cause of death was endocrine, nutritional, and metabolic diseases. The risk of death from amyloidosis increased with age and medium socioeconomic position.

Keywords: Amyloidosis; Cause of death; Incidence; Proportional hazards models; Survival rates.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have no financial conflicts of interest.

Figures

Figure 1
Figure 1. The age-standardized incidence of amyloidosis overall, by age group, sex, and year per 100, 000 persons between 2006 and 2017. (A) The age-standardized incidence of amyloidosis overall (middle), by sex (male: upper; female: lower), and by year per 100,000 persons between 2006 and 2017, (B) the age-standardized incidence of amyloidosis overall, (C) in males, and (D) in females by age group and by year per 100,000 persons between 2006 and 2017.
Figure 2
Figure 2. Survival curve for amyloidosis in Korean from 2006 through 2018. (A) Amyloidosis survival curve overall and by sex (p=non-significant); overall (middle), by sex (male: lower; female: upper) and (B) by age group (p<0.001)
See this image and copyright information in PMC

References

    1. Seo SR, Jang SY, Lee GY, et al. Prevalence of amyloidosis in Korea. Orphanet J Rare Dis. 2017;12:152. - PMC - PubMed
    1. National Health Insurance Service (NHIS) History of the NHIS [Internet] Wonju: National Health Insurance Service; c2021. [cited 2020 June 25]. Available from: https://www.nhis.or.kr/static/html/wbd/g/a/wbdga0203.html.
    1. Zomer AC, Uiterwaal CS, van der Velde ET, et al. Mortality in adult congenital heart disease: are national registries reliable for cause of death? Int J Cardiol. 2011;152:212–217. - PubMed
    1. Jang SY, Park TK, Kim DK. Survival and causes of death for Takayasu's arteritis in Korea: A retrospective population-based study. Int J Rheum Dis. 2021;24:69–73. - PubMed
    1. Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. 3rd ed. Philadelpia: Lippincott Williams & Wilkins; 2008.