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Review
. 2022 Oct 3:13:1014105.
doi: 10.3389/fphar.2022.1014105. eCollection 2022.

The bioactivities of sclareol: A mini review

Jianbo Zhou  1 , Xiaofang Xie  2 , Hailin Tang  3 , Cheng Peng  2 , Fu Peng  1
Affiliations
Review

The bioactivities of sclareol: A mini review

Jianbo Zhou et al. Front Pharmacol. .

Abstract

Sclareol, a diterpene alcohol isolated from the herbal and flavor plant clary sage (Salvia sclarea L.), is far-famed as the predominant ingredient in the refined oil of Salvia sclarea (L.). The empirical medicine of Salvia sclarea L. focused on various diseases, such as arthritis, oral inflammation, digestive system diseases, whereas the sclareol possessed more extensive and characteristic bioactivities, including anti-tumor, anti-inflammation and anti-pathogenic microbes, even anti-diabetes and hypertension. However, there is a deficiency of literature to integrate and illuminate the pharmacological attributes of sclareol based on well-documented investigations. Interestingly, sclareol has been recently considered as the potential candidate against COVID-19 and Parkinson's disease. Accordingly, the bioactive attributes of sclareol in cancer, inflammation, even pharmacochemistry and delivery systems are reviewed for comprehensively dissecting its potential application in medicine.

Keywords: bioactivities; cancer; delivery; inflammation; sclareol.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic overview of the effects and molecular mechanisms of Sclareol in cancers.
See this image and copyright information in PMC

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