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. 2023 May 2;83(9):1476-1489.
doi: 10.1158/0008-5472.CAN-22-1922.

The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid-Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Jia Liu #  1 , Ze-Xian Liu #  1   2 , Jia-Jun Li #  1 , Zhao-Lei Zeng #  1 , Jin-Hong Wang  1 , Xiao-Jing Luo  1 , Chau-Wei Wong  1 , Jia-Bo Zheng  1 , Heng-Ying Pu  1 , Hai-Yu Mo  1 , Hui Sheng  1 , Qi-Nian Wu  1 , Hao Li  1 , Gang Wan  3 , Bo Li  4 , De-Shen Wang  1   2 , Rui-Hua Xu  1   2 , Huai-Qiang Ju  1   2
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The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid-Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Jia Liu et al. Cancer Res. .

Abstract

Secretion of TNFα by tumor-associated macrophages stimulates cancer cells to upregulate lncRNA MALR, which induces ILF3 liquid-liquid phase separation and activation of HIF1α signaling to promote cancer progression.

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