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Review
. 2023 Jan;482(1):27-37.
doi: 10.1007/s00428-022-03430-4. Epub 2022 Oct 20.

The International Consensus Classification of acute myeloid leukemia

Olga K Weinberg  1 , Anna Porwit  2 , Attilio Orazi  3 , Robert P Hasserjian  4 , Kathryn Foucar  5 , Eric J Duncavage  6 , Daniel A Arber  7
Affiliations
Review

The International Consensus Classification of acute myeloid leukemia

Olga K Weinberg et al. Virchows Arch. 2023 Jan.

Abstract

Acute myeloid leukemias (AMLs) are overlapping hematological neoplasms associated with rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification and risk stratification are critical for treatment decisions. A group with expertise in the clinical, pathologic, and genetic aspects of these disorders developed the International Consensus Classification (ICC) of acute leukemias. One of the major changes includes elimination of AML with myelodysplasia-related changes group, while creating new categories of AML with myelodysplasia-related cytogenetic abnormalities, AML with myelodysplasia-related gene mutations, and AML with mutated TP53. Most of recurrent genetic abnormalities, including mutations in NPM1, that define specific subtypes of AML have a lower requirement of ≥ 10% blasts in the bone marrow or blood, and a new category of MDS/AML is created for other case types with 10-19% blasts. Prior therapy, antecedent myeloid neoplasms or underlying germline genetic disorders predisposing to the development of AML are now recommended as qualifiers to the initial diagnosis of AML. With these changes, classification of AML is updated to include evolving genetic, clinical, and morphologic findings.

Keywords: Acute myeloid leukemia; Classification; Genetic abnormalities.

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References

    1. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM et al (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391–2405 - DOI
    1. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al (1976) Proposals for the classification of the acute leukaemias French-American-British (FAB) co-operative group. Br J Haematol 33(4):451–458 - DOI
    1. Arber DA, Orazi A, Hasserjian RP (2022) International Consensus Classification of myeloid neoplasms and acute leukemia: integrating morphological, clinical, and genomic data. Blood blood 2022015850. https://doi.org/10.1182/blood.2022015850 .
    1. Vardiman J, Reichard K (2015) Acute myeloid leukemia with myelodysplasia-related changes. Am J Clin Pathol 144:29–43 - DOI
    1. Montalban-Bravo G, Kanagal-Shamanna R, Class CA, Sasaki K, Ravandi F, Cortes JE, Daver N, Takahashi K, Short NJ, DiNardo CD, Jabbour E, Borthakur G, Naqvi K, Issa GC, Konopleva M, Khoury JD, Routbort M, Pierce S, Do KA, Bueso-Ramos C, Patel K, Kantarjian H, Garcia-Manero G, Kadia TM (2020) Outcomes of acute myeloid leukemia with myelodysplasia related changes depend on diagnostic criteria and therapy. Am J Hematol 95(6):612–622 - DOI

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