Sex matters in liver fat regulation

David J Waxman¹, Rhonda D Kineman^{2

3}

Affiliations

¹ Department of Biology and Bioinformatics Program, Boston University, Boston, MA, USA.
² Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, USA.
³ Jesse Brown VA Medical Center, Chicago, IL, USA.

Comment

David J Waxman et al. Science. 2022.

. 2022 Oct 21;378(6617):252-253.

doi: 10.1126/science.ade7614. Epub 2022 Oct 20.

David J Waxman¹, Rhonda D Kineman^{2

3}

¹ Department of Biology and Bioinformatics Program, Boston University, Boston, MA, USA.
² Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, USA.
³ Jesse Brown VA Medical Center, Chicago, IL, USA.

Abstract

Growth hormone orchestrates a complex, sex-dependent balancing act.

An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice.
Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA. Nikkanen J, et al. Science. 2022 Oct 21;378(6617):290-295. doi: 10.1126/science.abn9886. Epub 2022 Oct 20. Science. 2022. PMID: 36264814 Free PMC article.