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Comment
. 2022 Dec;18(12):721-722.
doi: 10.1038/s41574-022-00759-3.

Timed high-fat diet feeding restores small bowel circadian rhythms

Samar A Tolba  1 , Vanessa A Leone  2
Affiliations
Comment

Timed high-fat diet feeding restores small bowel circadian rhythms

Samar A Tolba et al. Nat Rev Endocrinol. 2022 Dec.

Abstract

Host–microorganism circadian dynamics are key contributors to metabolic health. In addition, diet composition and timed feeding affect gut microbiota diurnal rhythms, with high-fat diets altering the composition of the gut microbiota and dampening circadian rhythms throughout the intestine. A recent study shows that time-restricted feeding of a high-fat diet restores the rhythms of small bowel host–microorganism interactions, preventing diet-induced obesity in mice.

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

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