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. 2022 Oct 4:13:867473.
doi: 10.3389/fphys.2022.867473. eCollection 2022.

CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia

Jiwoong Choi  1   2   3 , Kum Ju Chae  4 , Gong Yong Jin  4 , Ching-Long Lin  3   5   6 , Archana T Laroia  7 , Eric A Hoffman  7 , Chang Hyun Lee  7   8
Affiliations

CT-based lung motion differences in patients with usual interstitial pneumonia and nonspecific interstitial pneumonia

Jiwoong Choi et al. Front Physiol. .

Abstract

We applied quantitative CT image matching to assess the degree of motion in the idiopathic ILD such as usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP). Twenty-one normal subjects and 42 idiopathic ILD (31 UIP and 11 NSIP) patients were retrospectively included. Inspiratory and expiratory CT images, reviewed by two experienced radiologists, were used to compute displacement vectors at local lung regions matched by image registration. Normalized three-dimensional and two-dimensional (dorsal-basal) displacements were computed at a sub-acinar scale. Displacements, volume changes, and tissue fractions in the whole lung and the lobes were compared between normal, UIP, and NSIP subjects. The dorsal-basal displacement in lower lobes was smaller in UIP patients than in NSIP or normal subjects (p = 0.03, p = 0.04). UIP and NSIP were not differentiated by volume changes in the whole lung or upper and lower lobes (p = 0.53, p = 0.12, p = 0.97), whereas the lower lobe air volume change was smaller in both UIP and NSIP than normal subjects (p = 0.02, p = 0.001). Regional expiratory tissue fractions and displacements showed positive correlations in normal and UIP subjects but not in NSIP subjects. In summary, lung motionography quantified by image registration-based lower lobe dorsal-basal displacement may be used to assess the degree of motion, reflecting limited motion due to fibrosis in the ILD such as UIP and NSIP.

Keywords: computational biomechanics; computed tomography; idiopathic pulmonary fibrosis; image registration; interstitial lung disease; lung motionography; quantitative computed tomography image matching; usual interstitial pneumonia.

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Conflict of interest statement

EAH is a founder and shareholder of VIDA (Coralville, IA, United States). The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Air volumes at (A) inspiration and at (B) expiration, and (C) air volume changes between inspiration and expiration in the whole lung of normal, NSIP, and UIP subjects. ** denotes p < 0.05.
FIGURE 2
FIGURE 2
CT axial views (top), displacement vectors from expiration to inspiration (middle), and normalized dorsal and basal displacement magnitude maps on the entire conducting airway model (bottom) in representative (A) normal, (B) NSIP, and (C) UIP subjects.
FIGURE 3
FIGURE 3
Dorsal basal displacement in (A) the whole lung, (B) the upper lobes, and (C) the lower lobes of normal, NSIP, and UIP subjects. ** denotes p < 0.05.
FIGURE 4
FIGURE 4
Local TFs on (A,C,E,G) inspiration and on (B,D,F,H) expiration in the whole lung (A,B), upper and middle lobes (C,D), lower lobes (E,F), and upper–lower ratio (G,H) in normal, NSIP, and UIP subjects. ** denotes p < 0.05.
See this image and copyright information in PMC

References

    1. Albert R. K., Leasa D., Sanderson M., Robertson H. T., Hlastala M. P., Kirk W., et al. (1987). The prone position improves arterial oxygenation and reduces shunt in oleic-acid-induced acute lung injury. Am. Rev. Respir. Dis. 135, 628–633. 10.1164/arrd.1987.135.3.628 - DOI - PubMed
    1. Barr R. G., Ferraioli G., Palmeri M. L., Goodman Z. D., Garcia-Tsao G., Rubin J., et al. (2015). Elastography assessment of liver fibrosis: Society of radiologists in ultrasound consensus conference statement. Radiology 276, 845–861. 10.1148/radiol.2015150619 - DOI - PubMed
    1. Best A. C., Meng J., Lynch A. M., Bozic C. M., Miller D., Grunwald G. K., et al. (2008). Idiopathic pulmonary fibrosis: Physiologic tests, quantitative CT indexes, and CT visual scores as predictors of mortality. Radiology 246, 935–940. 10.1148/radiol.2463062200 - DOI - PubMed
    1. Chae K. J., Choi J., Jin G. Y., Hoffman E. A., Laroia A. T., Park M., et al. (2020). Relative regional air volume change maps at the acinar scale reflect variable ventilation in low lung attenuation of COPD patients. Acad. Radiol. 27 (11), 1540–1548. 10.1016/j.acra.2019.12.004 - DOI - PubMed
    1. Choi J., Hoffman E. A., Lin C. L., Milhem M. M., Tessier J., Newell J. D. (2017). Quantitative computed tomography determined regional lung mechanics in normal nonsmokers, normal smokers and metastatic sarcoma subjects. Plos One 12, e0179812. 10.1371/journal.pone.0179812 - DOI - PMC - PubMed

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