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Editorial
. 2023 Mar 15;207(6):653-655.
doi: 10.1164/rccm.202210-1925ED.

PAI-1 Drives Septation and Clinical Outcomes in Pleural Infection

Andrey A Komissarov  1 , Steven Idell  1
Affiliations
Editorial

PAI-1 Drives Septation and Clinical Outcomes in Pleural Infection

Andrey A Komissarov et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Relationship between PAI-1 (plasminogen activator inhibitor-1) and intrapleural septation and outcomes.
See this image and copyright information in PMC

Comment on

References

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    1. Idell S, James KK, Levin EG, Schwartz BS, Manchanda N, Maunder RJ, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest . 1989;84:695–705. - PMC - PubMed
    1. Idell S, Girard W, Koenig KB, McLarty J, Fair DS. Abnormalities of pathways of fibrin turnover in the human pleural space. Am Rev Respir Dis . 1991;144:187–194. - PubMed
    1. Beckert L, Brockway B, Simpson G, Southcott AM, Lee YCG, Rahman N, et al. Phase 1 trial of intrapleural LTI-01; single chain urokinase in complicated parapneumonic effusions or empyema. JCI Insight . 2019;5:e127470. - PMC - PubMed
    1. Bedawi EO, Kanellakis NI, Corcoran JP, Zhao Y, Hassan M, Asciak R, et al. The biological role of pleural fluid PAI-1 and sonographic septations in pleural infection: analysis of a prospectively collected clinical outcome study. Am J Respir Crit Care Med . 2023;207:731–739. - PMC - PubMed

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