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Comment
. 2022 Oct 20;29(10):1465-1466.
doi: 10.1016/j.chembiol.2022.09.006.

Localization matters in targeted protein degradation

Varun Jayeshkumar Shah  1 , Ivan Đikić  2
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Localization matters in targeted protein degradation

Varun Jayeshkumar Shah et al. Cell Chem Biol. .
Free article

Abstract

Many factors influence the efficiency of targeted protein degradation induced by proteolysis targeting chimeras (PROTACs). In this issue of Cell Chemical Biology,Simpson et al. (2022) highlight the impact of subcellular localization. Their study elucidates that the protein of interest exhibits different amenability to PROTAC-mediated degradation at different cellular compartments.

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Declaration of interests The authors declare no competing interests.

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