Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb;164(2):300-303.e3.
doi: 10.1053/j.gastro.2022.10.010. Epub 2022 Oct 19.

Infliximab and Tofacitinib Attenuate Neutralizing Antibody Responses Against SARS-CoV-2 Ancestral and Omicron Variants in Inflammatory Bowel Disease Patients After 3 Doses of COVID-19 Vaccine

Zhigang Liu  1 , James L Alexander  2 , Kathy Weitung Lin  3 ; VIP Study Investigators; Tariq Ahmad  4 , Katrina M Pollock  3 , Nick Powell  5
Collaborators, Affiliations

Infliximab and Tofacitinib Attenuate Neutralizing Antibody Responses Against SARS-CoV-2 Ancestral and Omicron Variants in Inflammatory Bowel Disease Patients After 3 Doses of COVID-19 Vaccine

Zhigang Liu et al. Gastroenterology. 2023 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(A–G) NT50 against SARS-CoV-2 ancestral strain and omicron in IBD patients treated with different immunosuppressive medications and healthy control individuals after 2 and 3 doses of vaccine. The horizontal bars represent the geometric mean and standard deviation. Wilcoxon signed-rank tests with Benjamini-Hochberg correction were performed. (H) The percentages of breakthrough infection in participants are stratified by neutralization titer ranges. ∗∗∗P < .001, ∗∗∗∗P < .0001.
See this image and copyright information in PMC

References

    1. Suthar A.B., et al. BMJ. 2022;377:e069317–e069323. - PMC - PubMed
    1. Altarawneh H.N., et al. N Engl J Med. 2022;387:21–34. - PMC - PubMed
    1. Kennedy NA, Janjua M, et al. Gut. Published July 28, 2022. https://doi.org/10.1136/gutjnl-2022-327570. - DOI
    1. Alexander J.L., Kennedy N.A., et al. Lancet Gastroenterol Hepatol. 2022;7:342–352. - PMC - PubMed
    1. Alexander J.L., Liu Z., Muñoz Sandoval D., Reynolds C., et al. Lancet Gastroenterol Hepatol. 2022;7:1005–1015. - PMC - PubMed

Supplementary References

    1. Alexander J.L., Kennedy N.A., et al. Lancet Gastroenterol Hepatol. 2022;7:342–352. - PMC - PubMed
    1. Kennedy N.A., Goodhand J.R., et al. Gut. 2021;70:865–875. - PubMed
    1. Kennedy NA, Janjua M, et al. Gut. Published July 28, 2022. https://doi.org/10.1136/gutjnl-2022-327570. - DOI
    1. Lin S.M., Kennedy N.A., Saifuddin A., Sandoval D.M., et al. Nat Commun. 2022;13:1379–1392. - PubMed
    1. Pollock K.M., et al. EClinicalMedicine. 2022;44

Publication types

Supplementary concepts