Learning and confirming in publicly funded antiviral trials
- PMID: 36272434
- PMCID: PMC9581520
- DOI: 10.1016/S1473-3099(22)00665-X
Learning and confirming in publicly funded antiviral trials
Conflict of interest statement
JFS received funding for COVID-19 antiviral projects as principal investigator from the Medical Research Council (MR/W015560/1) and as co-investigator from the National Institute for Health and Care Research (PANORAMIC 135366) and LifeArc and is a member of the independent data safety and monitoring committee for the GSK sotrovimab paediatric trial (VIR-7831-5005). AAA is employed on the Medical Research Council grant MR/W015560/1.
Comment on
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Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial.Lancet Infect Dis. 2023 Feb;23(2):183-195. doi: 10.1016/S1473-3099(22)00644-2. Epub 2022 Oct 19. Lancet Infect Dis. 2023. PMID: 36272432 Free PMC article. Clinical Trial.
References
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- Khoo SH, FitzGerald R, Saunders G, et al. Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. Lancet Infect Dis. 2022 doi: 10.1016/S1473-3099(22)00644-2. published online Oct 19. - DOI - PMC - PubMed
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- Sheiner LB. Learning versus confirming in clinical drug development. Clin Pharmacol Ther. 1997;61:275–291. - PubMed
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- Maisonnasse P, Guedj J, Contreras V, et al. Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates. Nature. 2020;585:584–587. - PubMed
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