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Observational Study
. 2022 Dec;40(10):557-561.
doi: 10.1016/j.eimce.2022.03.014. Epub 2022 Oct 20.

Congenital cytomegalovirus infection in newborns born to HIV-infected mothers

Luis M Prieto  1 , Daniel Blázquez Gamero  2 , Irene Rubio Mancha  3 , Belén Torres Pastor  3 , Cristina Epalza Ibarrondo  2 , Pablo Rojo Conejo  2 , José Tomás Ramos Amador  4 ; Working Group on cCMV in children exposed to HIV
Collaborators, Affiliations
Observational Study

Congenital cytomegalovirus infection in newborns born to HIV-infected mothers

Luis M Prieto et al. Enferm Infecc Microbiol Clin (Engl Ed). 2022 Dec.

Abstract

Introduction: Congenital citomegalovirus (CMVc) infection is more common in children exposed to HIV during pregnancy, with reported rates in pre-ART era from 2 to 7%. The use of combined antiretroviral treatment (ARTc) could be a determining factor in reducing this risk of CMV transmission. The aim of this study was to describe the epidemiology of CMVc infection in newborns of HIV-infected mothers at Hospital Universitario 12 de Octubre, Madrid, Spain, from 2000 to 2017.

Material and methods: An observational and retrospective study was carried out. Epidemiological and clinical variables were collected. Statistical analysis was performed with the SPSS 24.0 computer program.

Results: 288 mother-infant pairs were included in the study. We observed a CMVc rate of 2.1% (95% CI 0.9-4.9).

Conclusions: The rate of CMVc in HIV-exposed children observed was lower than that reported in pre-ARTc era but seems higher than those described in general population.

Keywords: Antiretroviral treatment; CMV; Congenital; Gestación; HIV; Infección congénita; Pregnancy; Tratamiento antirretroviral; VIH.

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