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. 2022 Oct 13:43:101136.
doi: 10.1016/j.ijcha.2022.101136. eCollection 2022 Dec.

Reclassification of coronary artery disease risk using genetic risk score among subjects with borderline or intermediate clinical risk

Razina A Ahmed  1 , Zhuqing Shi  1 , Andrew S Rifkin  1 , Jun Wei  1 , S Lilly Zheng  1 , Brian T Helfand  1   2   3 , Peter J Hulick  4   5 , Jonathan S H Woo  5 , Arman Qamar  5   6 , David J Davidson  5   6 , Liana K Billings  5 , Jianfeng Xu  1   2   4   3
Affiliations

Reclassification of coronary artery disease risk using genetic risk score among subjects with borderline or intermediate clinical risk

Razina A Ahmed et al. Int J Cardiol Heart Vasc. .
No abstract available

Keywords: Coronary artery disease (CAD); Reclassification; atherosclerotic cardiovascular disease (ASCVD); genetic risk score (GRS); polygenic risk score (PRS).

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Kaplan-Meier analysis for time to incident CAD from study recruitment in the UKB (White): a) four ASCVD risk groups in the entire cohort, b) with or without a family history (FH) of heart disease among subjects with borderline/intermediate-ASCVD risk, c) four GRSCAD risk groups (<0.5, 0.5–1.49, 1.5–3 and ≥ 3) among subjects with borderline/intermediate-ASCVD risk, and d) combination of FH status and GRSCAD risk groups.
Fig. 1
Fig. 1
Kaplan-Meier analysis for time to incident CAD from study recruitment in the UKB (White): a) four ASCVD risk groups in the entire cohort, b) with or without a family history (FH) of heart disease among subjects with borderline/intermediate-ASCVD risk, c) four GRSCAD risk groups (<0.5, 0.5–1.49, 1.5–3 and ≥ 3) among subjects with borderline/intermediate-ASCVD risk, and d) combination of FH status and GRSCAD risk groups.
Fig. 1
Fig. 1
Kaplan-Meier analysis for time to incident CAD from study recruitment in the UKB (White): a) four ASCVD risk groups in the entire cohort, b) with or without a family history (FH) of heart disease among subjects with borderline/intermediate-ASCVD risk, c) four GRSCAD risk groups (<0.5, 0.5–1.49, 1.5–3 and ≥ 3) among subjects with borderline/intermediate-ASCVD risk, and d) combination of FH status and GRSCAD risk groups.
Fig. 1
Fig. 1
Kaplan-Meier analysis for time to incident CAD from study recruitment in the UKB (White): a) four ASCVD risk groups in the entire cohort, b) with or without a family history (FH) of heart disease among subjects with borderline/intermediate-ASCVD risk, c) four GRSCAD risk groups (<0.5, 0.5–1.49, 1.5–3 and ≥ 3) among subjects with borderline/intermediate-ASCVD risk, and d) combination of FH status and GRSCAD risk groups.
Supplementary figure 1
Supplementary figure 1
Supplementary figure 2
Supplementary figure 2
See this image and copyright information in PMC

References

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