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Case Reports
. 2022 Oct 6:12:1034245.
doi: 10.3389/fonc.2022.1034245. eCollection 2022.

Primary urachal signet ring cell carcinoma: A case report

Qing Wang  1 , Xiaolong Chen  1 , Jianqing Zhang  2 , Yuting Luo  1 , Kehua Jiang  1
Affiliations
Case Reports

Primary urachal signet ring cell carcinoma: A case report

Qing Wang et al. Front Oncol. .

Abstract

Urachal signet ring cell carcinoma is a kind of rare but aggressive tumor, and a few cases have been reported previously. A 49-year-old male patient with primary complaints of increased frequency of urination, urodynia, and hematuria was diagnosed to have primary urachal signet ring cell carcinoma by our department. Multiple metastases were found in the sigmoid colon, terminal ileum, mesentery, and peritoneum during the operation, and palliative surgery involving partial cystectomy with en bloc resection of the urachus was then performed. A chemotherapy regimen of fluorouracil combined with cisplatin was made for this case. In addition, this patient also received anlotinib for targeted therapy. So far, this patient has done well on regular follow-up for 6 months and is in stable condition. We reported this additional urachal signet ring cell carcinoma case and conducted a literature review to strengthen our cognition of this disease.

Keywords: case report; diagnosis; signet ring cell carcinoma; treatment; urachal carcinoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Computed tomography of the current urachal signet ring cell carcinoma case. (A, B) A tumor with the size of 4.0 cm × 2.7 cm × 4.0 cm and progressive annular enhancement was observed in the anterior wall of the bladder. The mass in the trigone of the bladder was confirmed to be a blood clot via cystoscopy. (C) The tumor extended superiorly up to just below the umbilicus.
Figure 2
Figure 2
Representative immunohistochemical results of the current urachal signet ring cell carcinoma case.
Figure 3
Figure 3
Treatment timeline of the current urachal signet ring cell carcinoma case.
See this image and copyright information in PMC

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