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. 2022 Oct 5:10:1024864.
doi: 10.3389/fpubh.2022.1024864. eCollection 2022.

Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term

Qian Zhang  1   2 , Miao Guo  3 , Tianyi Chen  4 , Huizhi Cheng  2 , Qianwen Yang  2 , Zhuohui Zhao  4 , Rong She  1 , Xiaoyan Yang  1 , Wen Xiao  5 , Xu Yang  1   6 , Lijuan Li  1   2
Affiliations

Walking and taking vitamin C alleviates oxidative stress and inflammation in overweight students, even in the short-term

Qian Zhang et al. Front Public Health. .

Abstract

Objective: Obese or overweight is a risk factor for some chronic diseases, and oxidative stress and inflammation may be one of the molecular mechanisms leading to the persistence of these chronic diseases. Discovering interventions to alleviate oxidative stress and inflammation in the overweight/obese population, is very important for public health and health education.

Methods: A two-week panel intervention study (Run 0-Run 1-Run 2) was conducted. The subjects were 77 overweight/obese undergraduates attending Dali University, with a BMI>24 kg/m2. The physical indices measured at the end of each run included BMI, waist circumference, serum ROS, TNF-α, IL-1β and urinary 8-OHdG. Students were allocated to one of four intervention groups: No intervention (control); walking; taking vitamin C; and walking + taking vitamin C.

Results: The results demonstrated (1) Walking significantly alleviated ROS levels, and this was consistent in Run 1 and Run 2; (2) During Run1, all three intervention modes reduced levels of 8-OHdG, but there was a statistically insignificant increase during Run 2; (3) No alleviating effects of the three intervention modes on TNF-α levels during Run 1 and Run 2 were observed; (4) The alleviating effects of the three intervention modes on IL-1β levels during Run 1 and Run 2 were clear.

Conclusion: Walking and taking vitamin C can reduce levels of ROS, 8-OHdG and IL-1β, but not TNF-α, in overweight/obese participants. These interventions may become potential preventive measures for the overweight against obese-induced oxidative stress and inflammation.

Keywords: alleviation; inflammatory cytokine; intervention; overweight/obesity; oxidative stress; panel study; vitamin C; walking.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The research protocol for this panel study.
Figure 2
Figure 2
Results of RM-ANOVA. [(A–D) are for ROS in Run0, Run1 and Run2 groups, (E–H) are for 8-OHdG in Run0, Run1 and Run2 groups, (I–L) are for TNF-α in Run0, Run1 and Run2 groups, and (M–P) are for IL-1β in Run0, Run1 and Run2 groups. Comparison for research courses with RM-ANOVA, *: the difference is significant (p < 0.05); **: the difference is very significant (p < 0.01)].
Figure 3
Figure 3
The results of linear mixed effects model analysis.
Figure 4
Figure 4
Schematic diagram of energy intake, oxidative stress and inflammation, and Vit C protective effects.
See this image and copyright information in PMC

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References

    1. Galbraith JK. The Affluent Society, 4th ed. Boston: Houghton Mifflin Company; (1984).
    1. Levine TB, Levine AB. Metabolic Syndrome and Cardiovascular Disease. 1st ed.; Singapore: Elsevier Pte Ltd (2010) ISBN: 978-7-117-13464-4/R.13465
    1. Xiao W, Yang X. A key issue of China national health: Excess energy intake and oxidative inflammation. China J Chin Materia Medica. (2021) 47:853–61. 10.19540/j.cnki.cjcmm.20210929.601 - DOI - PubMed
    1. Da Silva VR, Moreira EA, Wilhelm-Filho D, De Miranda JX, Benincá JP, Vigil SV, et al. . Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up. Eu J Clin Nutri. (2012) 66:891–9. 10.1038/ejcn.2012.17 - DOI - PubMed
    1. Mah E, Matos MD, Kawiecki D, Ballard K, Guo Y, Volek JS, et al. . Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men. J Am Dietetic Association. (2011) 111:737–43. 10.1016/j.jada.2011.02.003 - DOI - PubMed

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