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. 2022 Oct 14:2022:9988513.
doi: 10.1155/2022/9988513. eCollection 2022.

Association between ERCC1 Gene Polymorphism (rs11615) and Colorectal Cancer Susceptibility: A Meta-Analysis of Medical Image Fusion and Safety Applications

Min Liu  1 , Zhifeng Qiu  2 , Qi Yang  3
Affiliations

Association between ERCC1 Gene Polymorphism (rs11615) and Colorectal Cancer Susceptibility: A Meta-Analysis of Medical Image Fusion and Safety Applications

Min Liu et al. Comput Math Methods Med. .

Abstract

Colorectal cancer (CRC) is a malignant tumor of the colorectal mucosa epithelial tissue transformed. The fusion of data for medical imaging has become a central issue in such biomedical applications as image-guided surgery and radiotherapy. Currently, CRC has been one of the most threatening tumors affecting people's health worldwide. The excision repair cross-complementation group 1 (ERCC1) is a key enzyme for nucleotide excision repair (NER). Emerging epidemiological studies have indicated that the presence of colorectal cancer (CRC) may be relevant to the ERCC1 rs11615 genetic polymorphism. However, the results of ERCC1 rs11615 on CRC in these studies are controversial. We searched PubMed, Web of Science, Embase, CNKI, and CBM databases for the effects of ERCC1 rs11615 variant on CRC development. There was no meta-analysis focused on the diagnosis of colorectal cancer with ERCC1 rs11615 variant. We creatively carried out a meta-analysis of nine case-control studies and used Stata (version 12.0) software to integrate the pooled odds ratios (ORs) corresponding to a 95% confidence interval (CI) of overall and subgroup analysis. Our results suggest that a significant correlation was observed between rs11615 and the susceptibility of CRC OR 95% CI = 1.13 (1.04-1.23) under an allele genetic model and OR 95% CI = 1.14 (1.01-1.30) under a dominant genetic model for overall CRC. Significant statistical difference was also noted in Asians rather than Caucasians based on the ethnicity subgroups. These results suggested that there is a certain association between rs11615 and the susceptibility of colorectal cancer in the Asian populations.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flow diagram for screening of articles in this meta-analysis.
Figure 2
Figure 2
Forest plots of CRC risk associated with ERCC1 rs11615 under different models stratification by ethnicity. (a) Allele model (T vs. C). (b) Dominant model (TT + TC vs. CC). (c) Recessive model (TT vs. TC + CC). (d) Homozygote model (TT vs. CC).
Figure 3
Figure 3
Begg's funnel plots of the association between ERCC1 rs11615 genetic polymorphism and CRC risk under different models. (a) Allele model (T vs. C). (b) Dominant model (TT + TC vs. CC). (c) Recessive model (TT vs. TC + CC). (d) Homozygote model (TT vs. CC).
Figure 4
Figure 4
Sensitivity analyses of the summary odds ratio coefficients on the relationships of ERCC1 rs11615 genetic polymorphisms.
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