Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Oct 12:2022:8615420.
doi: 10.1155/2022/8615420. eCollection 2022.

Symmetrical Peripheral Gangrene: Report of Three Cases

Affiliations
Case Reports

Symmetrical Peripheral Gangrene: Report of Three Cases

Héctor Acosta et al. Case Rep Crit Care. .

Abstract

Symmetrical peripheral gangrene (SPG) is a rare clinical syndrome characterized by an acute onset of ischemic damage in two or more extremities without obstruction or vasculitis of supplying vessels. Body parts commonly affected include toes, hands, scrotum, and earlobes, increasing the risk of limb amputation and impairing the quality of life. The vascular injury mechanism is disseminated intravascular coagulation. SPG may manifest unpredictably in conditions associated with septic shock, low output states, vasospastic conditions, myeloproliferative disorders, or hyperviscosity syndrome. A review on the topic is presented based on a 3-case series of SPG that required amputation of fingers and toes after the administration of vasopressors in a septic shock context.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Case 1 lesions.
Figure 2
Figure 2
Intraoperative levels of amputation and functionality after complete wound healing.
Figure 3
Figure 3
Case 2 lesions.

References

    1. Dong J., Zhang L., Rao G., Zhao X. Complicating symmetric peripheral gangrene after dopamine therapy to patients with septic shock. Journal of Forensic Sciences . 2015;60(6):1644–1646. doi: 10.1111/1556-4029.12844. - DOI - PubMed
    1. Ruffin N., Vasa C. V., Breakstone S., Axman W. Symmetrical peripheral gangrene of bilateral feet and unilateral hand after administration of vasopressors during septic shock. Case Reports . 2018;2018:p. bcr-2017. doi: 10.1136/bcr-2017-223602. - DOI - PMC - PubMed
    1. Davis M. P., Byrd J., Lior T., Rooke T. W. Symmetrical peripheral gangrene due to disseminated intravascular coagulation. Archives of Dermatology . 2001;137(2):139–140. - PubMed
    1. Molos M. A., Hall J. C. Symmetrical peripheral gangrene and disseminated intravascular coagulation. Archives of Dermatology . 1985;121(8):1057–1061. doi: 10.1001/archderm.1985.01660080111027. - DOI - PubMed
    1. Schuh T. E., Erdmann D., Levin L. S. Symmetrische periphere Gangrän unbekannter Ätiologie. Die Chirurgie . 2002;73(6):638–641. doi: 10.1007/s00104-001-0417-x. - DOI - PubMed

Publication types

LinkOut - more resources