Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun;13(6):1007-1016.
doi: 10.1002/alr.23098. Epub 2022 Nov 8.

Rhinitis symptom in patients with self-reported allergic rhinitis is influenced by sensitization pattern: A cross-sectional study of China

Liting Wu  1 , Teng Zhang  2   3 , Wenting Luo  1 , Xianhui Zheng  1 , Hong Zhang  4 , Huali Ren  5 , Dongming Huang  6 , Guoping Li  7 , Chunhua Wei  8 , Linghua Dong  9 , Xin Sun  10 , Rongfang Zhang  11 , Yi Wang  12 , Peicun Hu  13 , Yuemin Chen  1 , Qi Zhao  2   3 , Chuangli Hao  14 , Baoqing Sun  1
Affiliations

Rhinitis symptom in patients with self-reported allergic rhinitis is influenced by sensitization pattern: A cross-sectional study of China

Liting Wu et al. Int Forum Allergy Rhinol. 2023 Jun.

Abstract

Background: Allergic rhinitis (AR) is characterized by distinct clinical heterogeneity and allergic sensitization patterns. We aimed to quantify rhinitis symptoms in patients with self-reported allergic rhinitis according to the potential sensitization patterns for relevant allergens in China.

Methods: We used latent class analysis (LCA; a subset of structural equation modeling) to independently cluster patients into different patterns of atopic sensitization in an unsupervised manner, based on specific immunoglobulin E tests. AR symptom severity was assessed by the visual analogue scale. We evaluated the association between the severity of AR and the allergen sensitization patterns.

Results: LCA revealed four phenotypes of atopic sensitization among 967 patients with self-report AR. We labeled latent classes as: Class 1, weed pollens and indoor sensitization (n = 74 [7.7%]); Class 2, weed pollen with low indoor sensitization (n = 275 [28.4%]); Class 3, low or no sensitization (n = 350 [36.2%]); and Class 4, house dust mite-dominated sensitization (n = 268 [27.7%]). AR was more severe in Class 2 compared to the other 3 classes, indicating that upper respiratory symptoms are more severe among patients with isolated seasonal rhinitis.

Conclusion: We have identified four sensitization patterns in patients with self-reported AR, which were associated with different clinical symptoms and comorbidities.

Keywords: allergen sensitization; allergic rhinitis; atopy; latent class analysis.

PubMed Disclaimer

References

REFERENCES

    1. Brozek JL, Bousquet J, Agache I, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017;140(4):950-958.
    1. Schmitt J, Wustenberg E, Kuster D, et al. The moderating role of allergy immunotherapy in asthma progression: results of a population-based cohort study. Allergy. 2020;75(3):596-602.
    1. Bousquet J, van Cauwenberge P. Allergic rhinitis and its impact on asthma (ARIA) In collaboration with the World Health Organisation. Prim Care Respir J. 2002;11(1):18-19.
    1. Li J, Huang Y, Lin X, et al. Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients. Respir Res. 2011;12:95.
    1. Hose AJ, Depner M, Illi S, et al. Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts. J Allergy Clin Immunol. 2017;139(6):1935-1945.e1912.

Publication types

LinkOut - more resources