PRKCD as a potential therapeutic target for chronic obstructive pulmonary disease

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease characterized by progressive airflow limitation and abnormal lung function due to noxious particles and gases. Although many measures are available, COPD remains one of the leading causes of morbidity and mortality worldwide. Therefore, there is an urgent need to discover novel potential therapeutic targets for COPD. Protein kinase C delta (PRKCD) is a member of thePKCfamily and possesses various biological properties. Recently, PRKCD has been reported to play an important role in the pathogenesis of COPD. However, the mechanisms of PRKCD on COPD are not fully elucidated.

Aim: In this review, we will discuss the roles and mechanisms of PRKCD involved in the development of COPD.

Methods: We systematically summarized the studies on the research progress of PRKCD in COPD based on MEDLINE/PubMed databases.

Conclusions: PRKCD contributes to the development of COPD by promoting inflammatory response, apoptosis, mitochondrial dysfunction and MUC5AC hypersecretion. These data provide evidence that PRKCD might be a potential therapeutic target for COPD.

Keywords: Apoptosis; Chronic obstructive pulmonary disease; Inflammation; MUC5AC; Mitochondrial function; Protein kinase C delta.