Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 14;8(10):e11073.
doi: 10.1016/j.heliyon.2022.e11073. eCollection 2022 Oct.

Anti-seizure medications and quality of life in person with epilepsy

Rekha Dwivedi  1 , Prabhakar Tiwari  2 , Monika Pahuja  3 , Rima Dada  2 , Manjari Tripathi  1
Affiliations

Anti-seizure medications and quality of life in person with epilepsy

Rekha Dwivedi et al. Heliyon. .

Abstract

Objective: The goal of this study was to determine the effects of mono-, bi-, and polytherapy anti-seizure medications (ASMs) in terms of seizure reduction and quality of life (QOL) in persons with epilepsy (PWE).

Methods: A cross-sectional observational study was conducted. All PWE with age <75 years were recruited and further classified into two groups: responders and non-responders, based on the response of the ASMs to the treatments for reduced seizure frequency since the last one year. Other demographic and clinical data such as seizure frequency, type of seizures, age at onset of seizures, and information about ASMs with their daily doses were assessed for the descriptive analysis. The quality of life was assessed in randomly selected PWE (n = 100) using the quality of life in epilepsy inventory-31 (QOLIE-31) in adults.

Results: With a total of 486 PWE, the median age (years) was comparable in both groups. Out of these the non-responders group was found to be significantly higher (77.8%) than the responders group (22.2%). In the responders group, the percentage of PWE who were on monotherapy was significantly higher (51.85 %) than those who were on polytherapy (17.59%), whereas in the non-responders group, 21.16% of PWE were on monotherapy and 44.86% were on polytherapy. The duration of epilepsy was similar in both groups, but the average seizure frequency was significantly higher in the non-responders. In QOL assessments, 43% of PWE were observed in the responders group, whereas 57% of PWE were found in the non-responders group. The overall comparative QOL scores were also significantly higher (p < 0.0001) in the responders group as compared to the non-responders group.

Conclusion: Our findings revealed that those PWE who were on monotherapy showed better reduction in seizure frequency and improved QOL in responder groups as compared to non-responder groups.

Keywords: Anti-seizure medications; Epilepsy; Monotherapy; Non responders group (NRG); Polytherapy; Quality of life; Responders group (RG).

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of patients who were on monotherapy of anti-seizure medications (ASMs): We have shown a comparative individualized anti-seizure medication pattern that was prescribed in the responders group and the non-responders group.
See this image and copyright information in PMC

References

    1. Epilepsy. https://www.who.int/health-topics/epilepsy#tab=tab_1
    1. Sirven J.I. Epilepsy: a spectrum disorder. Cold Spring Harb. Perspect Med. 2015;5(9):a022848. - PMC - PubMed
    1. Satishchandra P., Santhosh N., Sinha S. Epilepsy: Indian perspective. Ann. Indian Acad. Neurol. 2014;17(5):3. - PMC - PubMed
    1. Schmidt D., Schachter S.C. Drug treatment of epilepsy in adults. BMJ. 2014;348(2):g254. - PubMed
    1. Alqahtani F., Imran I., Pervaiz H., et al. Non-pharmacological interventions for intractable epilepsy. Saudi Pharmaceut. J. 2020;28(8):951–962. - PMC - PubMed

LinkOut - more resources