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. 2022 Nov 25;85(11):2641-2649.
doi: 10.1021/acs.jnatprod.2c00719. Epub 2022 Oct 25.

Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564

Yoshihiro Watanabe  1   2 , Kodai Hachiya  3 , Akari Ikeda  1   2 , Kenichi Nonaka  1   2 , Mayuka Higo  1   2 , Reiko Muramatsu  1 , Chikako Noguchi  1 , Masako Honsho  1 , Yukihiro Asami  1   2 , Yuki Inahashi  1   2 , Tomoyasu Hirose  1   2 , Hidehito Matsui  1   2 , Toshiaki Sunazuka  1   2 , Hideaki Hanaki  1   2 , Takahiro Ishii  4 , Toshiaki Teruya  5 , Rei Hokari  1   2 , Aki Ishiyama  1   2 , Masato Iwatsuki  1   2
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Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564

Yoshihiro Watanabe et al. J Nat Prod. .

Abstract

Two new antiplasmodial peptides, named koshidacins A (1) and B (2), were discovered from the culture broth of the Okinawan fungus Pochonia boninensis FKR-0564. Their structures, including absolute configurations, were elucidated by a combination of spectroscopic methods and chemical derivatization. Both compounds showed moderate in vitro antiplasmodial activity against Plasmodium falciparum strains, with IC50 values ranging from 17.1 to 0.83 μM. In addition, compound 2 suppressed 41% of malaria parasites in vivo when administered intraperitoneally at a dose of 30 mg/kg/day for 4 days.

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