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Comment
. 2023 Mar;33(3):189-190.
doi: 10.1038/s41422-022-00740-9.

mTOR gets greasy: lysosomal sensing of cholesterol

Liron Bar-Peled  1 , Dudley W Lamming  2   3
Affiliations
Comment

mTOR gets greasy: lysosomal sensing of cholesterol

Liron Bar-Peled et al. Cell Res. 2023 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1. The regulation of mTORC1 activity.
mTORC1 is recruited to the lysosomal surface by heterodimers of the Rag family of small GTPases; the nucleotide-binding state of the Rags is controlled by protein complexes including the Ragulator, a GEF for RagA and RagB; and GATOR1, a GAP for RagA and RagB. Cholesterol binds to SLC38A9 and regulates the Ragulator-Rag GTPase complex. Shin and colleagues have shown that cholesterol is sensed by the GPCR LYCHOS; when cholesterol is high, LYCHOS activates mTORC1 activity by sequestering GATOR1. This figure is adapted from.
See this image and copyright information in PMC

Comment on

  • Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
    Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim CY, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, Park E, Covey DF, Laplante M, Evers AS, Zoncu R. Shin HR, et al. Science. 2022 Sep 16;377(6612):1290-1298. doi: 10.1126/science.abg6621. Epub 2022 Aug 25. Science. 2022. PMID: 36007018 Free PMC article.

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