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Case Reports
. 2022 Jul 14:42:206.
doi: 10.11604/pamj.2022.42.206.34595. eCollection 2022.

Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation: a case report

Asmaa El Kebir  1   2 , Evrard Niyonkuru  1   2 , Mahmoud Alafifi  2   3 , Nisrine Bennani Guebessi  1   2 , Mehdi Karkouri  1   2 , Rachid Aboutaieb  2   3
Affiliations
Case Reports

Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation: a case report

Asmaa El Kebir et al. Pan Afr Med J. .

Abstract

Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation is a very extremely rare tumor and only few cases have been reported in the literature. Here we report a case of a 37-year-old woman who presented with a pain and a palpable mass in the right flank. The abdominal computed tomography (CT) scan found a renal tumor and the patient underwent a right radical nephrectomy with adrenal gland resection. After the histological examination of the specimen completed by immunohistochemical and molecular study, a diagnosis of chromophobe renal cell carcinoma with liposarcomatous dedifferentiation was made. The patient received adjuvant chemotherapy. Afterwards, she developed bone metastasis and died 13 months after the surgery. Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation is a rare tumor associated with a poor prognosis and a metastatic potential.

Keywords: Chromophobe renal cell carcinoma; Kidney neoplasm; case report; liposarcomatous dedifferentiation.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
gross examination of the specimen showing a white beige neoplasm, encapsulated, with yellowish, necrotic and hemorrhagic areas (blue arrow)
Figure 2
Figure 2
histological examination, hematoxylin and eosin stain, (A, 10x) and (B, 20x) showing the chromophobe renal cell carcinoma and high-grade sarcomatous component with sheets lipoblasts pleomorphics
Figure 3
Figure 3
immunohistochemistry, (A, 20x) and (B, 40x); chromophobe renal cell carcinoma showing positive reactivity for cytokeratin AE1/AE3
See this image and copyright information in PMC

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