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Review
. 2022 Oct 10:20:5652-5660.
doi: 10.1016/j.csbj.2022.10.009. eCollection 2022.

Non-coding antisense transcripts: fine regulation of gene expression in cancer

Francisco Santos  1 , Ana Maria Capela  1 , Francisca Mateus  1 , Sandrina Nóbrega-Pereira  1 , Bruno Bernardes de Jesus  1
Affiliations
Review

Non-coding antisense transcripts: fine regulation of gene expression in cancer

Francisco Santos et al. Comput Struct Biotechnol J. .

Abstract

Natural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described and targeted mechanisms. NATs represent the intricate complexity of the genome organization and constitute another layer of potential targets in disease. Here, we focus on the interesting and unique role of non-coding NATs in cancer, paying particular attention to those acting as miRNA sponges.

Keywords: Antisense transcripts; Cancer; Long non-coding RNAs; ceRNAs; lncRNAs.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
NAT classification and mechanisms of regulation . Sense and antisense pairs can be head-to-head, tail-to-tail or fully overlapped . NATs can regulate the genes in the vicinity (cis-NATs) or at large distance in the genome (trans-NATs) . A proposed mechanism of action may involve a direct impact on the transcription of the cognate genes , through interference with the process of splicing, affecting the DNA or chromatin epigenetic signature or affect mature RNAs by RNA/RNA interactions, through DICER-dependent or -independent mechanisms , .
See this image and copyright information in PMC

References

    1. Djebali S., Davis C.A., Merkel A., et al. Landscape of transcription in human cells. Nature. 2012;489(7414):101–108. doi: 10.1038/nature11233. - DOI - PMC - PubMed
    1. Carninci P., Kasukawa T., Katayama S., et al. The transcriptional landscape of the mammalian genome. Science (80-) 2005;309(5740):1559–1563. 309/5740/1559 [pii]10.1126/science.1112014. - PubMed
    1. Maeda N., Kasukawa T., Oyama R., et al. Transcript annotation in FANTOM3: Mouse gene catalog based on physical cDNAs. PLoS Genet. 2006;2(4):498–503. doi: 10.1371/journal.pgen.0020062. - DOI - PMC - PubMed
    1. Dunham I., Kundaje A., Aldred S.F., et al. An integrated encyclopedia of DNA elements in the human genome. Nature. 2012;489(7414):57–74. doi: 10.1038/nature11247. - DOI - PMC - PubMed
    1. Guttman M., Rinn J.L. Modular regulatory principles of large non-coding RNAs. Nature. 2012;482(7385):339–346. doi: 10.1038/nature10887. - DOI - PMC - PubMed

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