Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Oct 20;10(10):e6469.
doi: 10.1002/ccr3.6469. eCollection 2022 Oct.

Successful rechallenge with cisplatin following cisplatin induced ischemic cerebrovascular accident in a patient with small cell lung cancer

Farah Rashid  1 , Nabil E Omar  2 , Hassan Aaekl  3 , Ussama Al Homsi  3 , Alaaeldin Shablak  3
Affiliations
Case Reports

Successful rechallenge with cisplatin following cisplatin induced ischemic cerebrovascular accident in a patient with small cell lung cancer

Farah Rashid et al. Clin Case Rep. .

Abstract

Cisplatin is a widely used platinum-based chemotherapy agent. Its common adverse effects are neuropathy, nephrotoxicity, electrolyte abnormality, and rarely causing thrombotic vascular toxicity. We present a patient known to have small-cell lung cancer who developed ischemic cerebrovascular accident (CVA) after receiving chemotherapy regimen including cisplatin.

Keywords: cerebrovascular accident; cisplatin; cisplatin induced stroke; small cell lung cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there was conflict no of interest regarding the publication of this case report.

Figures

FIGURE 1
FIGURE 1
Initial MRI head showing normal study
FIGURE 2
FIGURE 2
CT Head showing hypodense lesion in left temporal lobe (arrow) possible ischemic foci.
FIGURE 3
FIGURE 3
MRI Head showing multiple acute ischemic infarctions (arrows) in left basal ganglia and left cerebral hemisphere.
See this image and copyright information in PMC

References

    1. Kalemkerian GP, Akerley W, Bogner P, et al. Small cell lung cancer. J Natl Compr Canc Netw. 2013;11(1):78‐98. doi: 10.6004/JNCCN.2013.0011 - DOI - PMC - PubMed
    1. Cancer Statistics Review , 1975–2017 ‐ SEER statistics. Accessed January 29, 2022. https://seer.cancer.gov/archive/csr/1975_2017/
    1. Ettinger DS, Aisner J. Changing face of small‐cell lung cancer: real and artifact. J Clin Oncol. 2006;24(28):4526‐4527. doi: 10.1200/JCO.2006.07.3841 - DOI - PubMed
    1. Amini A, Byers LA, Welsh JW, Komaki RU. Progress in the management of limited‐stage small cell lung cancer. Cancer. 2014;120(6):790‐798. doi: 10.1002/CNCR.28505 - DOI - PMC - PubMed
    1. Dasari S, Bernard Tchounwou P. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014;740:364‐378. doi: 10.1016/J.EJPHAR.2014.07.025 - DOI - PMC - PubMed

Publication types

LinkOut - more resources