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Editorial
. 2022 Nov;11(21):e026873.
doi: 10.1161/JAHA.122.026873. Epub 2022 Oct 26.

Vaccine-Triggered Acute Autoimmune Myocarditis: Defining, Detecting, and Managing an Apparently Novel Condition

Saidi A Mohiddin  1   2 , Oliver Guttmann  1   3 , Federica Marelli-Berg  2
Affiliations
Editorial

Vaccine-Triggered Acute Autoimmune Myocarditis: Defining, Detecting, and Managing an Apparently Novel Condition

Saidi A Mohiddin et al. J Am Heart Assoc. 2022 Nov.
No abstract available

Keywords: COVID‐19; myocarditis; vaccines.

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Figures

Figure
Figure. Myocarditis Is a Rare Complication Following Vaccination: A Graphic Summary.
The overwhelming proportion of exposed individuals mount normal immune responses and do not develop myocardial inflammation. In a very small fraction of previously healthy susceptible hosts, antigen and/or immunostimulation trigger self‐limiting immune‐mediated myocardial injury. The mechanisms underlying this maladaptive immune response, and how they relate to acquired/innate host characteristics and/or to antigen/immunostimulant factors, are largely unknown. It is hypothesized that some individuals with prior myocardial injury may have latent adaptive immunological memory for cardiac self‐antigen(s) and may be at greater risk of myocarditis when exposed to these or similar triggers. In such cases, acquired host characteristics may be of central importance in determining outcomes. A small number of individuals with postvaccine myocarditis may progress on a more fulminant acute course, or develop chronic myocarditis. Detecting these cases, with a view to therapeutic intervention, is the ultimate purpose of the proposed clinical approach. AM indicates acute myocarditis.
See this image and copyright information in PMC

Comment on

References

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