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Review
. 2022 Oct;35 Suppl 3(Suppl 3):30-33.
doi: 10.37201/req/s03.07.2022. Epub 2022 Oct 24.

Optimization of antimicrobial treatment in sepsis

J R Azanza Perea  1
Affiliations
Review

Optimization of antimicrobial treatment in sepsis

J R Azanza Perea. Rev Esp Quimioter. 2022 Oct.

Abstract

Sepsis represents a serious risk to the life of any patient, which is why it is crucial to start an effective treatment in all its extremes as soon as possible, that is, the chosen antibiotics must have activity against the pathogen that produces the condition and, in addition, they must be dosed considering the patient's situation in all its extremes. It should be considered that it will be necessary to adjust the dose when there is edema (drugs with reduced volume of distribution), hypoproteinemia (drugs bound to proteins in a high proportion), obesity, and also when they require the use of external techniques such as ECMO or any of the different types of hemodialysis and hemofiltration.

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Conflict of interest statement

Authors declare no conflict of interest

Figures

Figure 1
Figure 1
Bound protein
Figure 2
Figure 2
Log P and adjustment of dose to weight
See this image and copyright information in PMC

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