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. 2022 Oct 14;44(10):4888-4901.
doi: 10.3390/cimb44100332.

Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes

Anastasiya S Babkina  1 , Mikhail Ya Yadgarov  1 , Irina V Ostrova  1 , Vladislav E Zakharchenko  1 , Artem N Kuzovlev  1 , Andrey V Grechko  1 , Maxim A Lyubomudrov  1 , Arkady M Golubev  1
Affiliations

Serum Levels of VEGF-A and Its Receptors in Patients in Different Phases of Hemorrhagic and Ischemic Strokes

Anastasiya S Babkina et al. Curr Issues Mol Biol. .

Abstract

Vascular endothelial growth factors (VEGFs) are important regulators of angiogenesis, neuroprotection, and neurogenesis. Studies have indicated the association of VEGF dysregulation with the development of neurodegenerative and cerebrovascular diseases. We studied the changes in serum levels of VEGF-A, VEGFR-1, and VEGFR-2 in patients at various phases of ischemic and hemorrhagic strokes. Quantitative assessment of VEGF-A, VEGFR-1, and VEGFR-2 in serum of patients with hemorrhagic or ischemic stroke was performed by enzyme immunoassay in the hyper-acute (1−24 h from the onset), acute (up to 1−7 days), and early subacute (7 days to 3 months) phases of stroke, and then compared with the control group and each other. Results of our retrospective study demonstrated different levels of VEGF-A and its receptors at various phases of ischemic and hemorrhagic strokes. In ischemic stroke, increased VEGFR-2 level was found in the hyper-acute (p = 0.045) and acute phases (p = 0.024), while elevated VEGF-A and reduced VEGFR-1 levels were revealed in the early subacute phase (p = 0.048 and p = 0.012, respectively). In hemorrhagic stroke, no significant changes in levels of VEGF-A and its receptors were identified in the hyper-acute phase. In the acute and early subacute phases there was an increase in levels of VEGF-A (p < 0.001 and p = 0.006, respectively) and VEGFR-2 (p < 0.001 and p = 0.012, respectively). Serum levels of VEGF-A and its receptors in patients with hemorrhagic and ischemic stroke indicate different pathogenic pathways depending on the phase of the disease.

Keywords: VEGFR-1; VEGFR-2; brain damage; hemorrhagic stroke; ischemic stroke; vascular endothelial growth factor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Changes in serum VEGF-A level in patients with ischemic or hemorrhagic stroke.
Figure 2
Figure 2
Changes in serum VEGFR-1 level in patients with ischemic or hemorrhagic stroke.
Figure 3
Figure 3
Changes in serum VEGFR-2 level in patients with ischemic or hemorrhagic stroke.
Figure 4
Figure 4
The relationship between the levels of VEGF-A and age in the control group.
See this image and copyright information in PMC

References

    1. Mazilina A.N., Skalny A.V., Fesyun A.D., Yakovlev M.Y., Savko S.A., Namiot E.D. Review of the Elemental Status in Blood Serum in Patients with Ischemic Stroke. Bull. Rehabil. Med. 2022;21:104–113. doi: 10.38025/2078-1962-2022-21-1-104-113. - DOI
    1. Tokshilykova A., Kabdrakhmanova G., Sarkulova Z., Utepkaliyeva A., Khamidulla A., Urasheva Z. Modern Aspects of Etiopathogenesis, Diagnosis and Treatment of Hemorrhagic Stroke NcJSC. West Kazakhstan Marat Ospanov Medical University; Aktobe city, Kazakhstan: 2020.
    1. Wijerathne H., Witek M.A., Baird A.E., Soper S.A. Liquid biopsy markers for stroke diagnosis. Expert Rev. Mol. Diagn. 2020;20:771–788. doi: 10.1080/14737159.2020.1777859. - DOI - PMC - PubMed
    1. Simpkins A.N., Janowski M., Oz H.S., Roberts J., Bix G., Doré S., Stowe A.M. Biomarker Application for Precision Medicine in Stroke. Transl. Stroke Res. 2020;11:615–627. doi: 10.1007/s12975-019-00762-3. - DOI - PMC - PubMed
    1. Brunkhorst R., Pfeilschifter W., Foerch C. Astroglial proteins as diagnostic markers of acute intracerebral hemorrhage—Pathophysiological background and clinical findings. Transl. Stroke Res. 2010;1:246–251. doi: 10.1007/s12975-010-0040-6. - DOI - PubMed

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