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. 2022 Nov;28(11):2304-2307.
doi: 10.3201/eid2811.221040.

Polyclonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae, France, 2013-2021

Cecile Emeraud, Aurélien Birer, Delphine Girlich, Agnès B Jousset, Elodie Creton, Thierry Naas, Rémy A Bonnin, Laurent Dortet

Polyclonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae, France, 2013-2021

Cecile Emeraud et al. Emerg Infect Dis. 2022 Nov.

Abstract

During 2013-2021, increased prevalence of oxacillinase 232-producing Enterobacterales was observed in France, mostly driven by its emergence in Klebsiella pneumoniae. Whole-genome sequencing identified that oxacillinase 232-producing K. pneumoniae belonged to 14 sequence types (STs), among which 2 polyclonal high-risk clones, ST-231 and ST-2096, were overrepresented.

Keywords: Enterobacterales; France; Klebsiella pneumoniae; OXA-232; antimicrobial resistance; carbapenemase; epidemiology; oxacillin.

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Figures

Figure 1
Figure 1
OXA-232–producing Enterobacterales received at the National Reference Center for Carbapenem-Resistant Enterobacterales, France 2013–2021. A) Evolution of several OXA-232–producing Enterobacterales, by species (top of panel) and carbapenemase variant (bottom). B) Evolution of distribution of ST among all OXA-232–producing K. pneumoniae. C) Evolution of distribution of ST among NDM and OXA-232–coproducing K. pneumoniae. NDM, New Delhi metallo-β-lactamase; OXA, oxacillinase; ST, sequence type.
Figure 2
Figure 2
Phylogenetic relationship of OXA-232–producing K. pneumoniae ST-231 (A) and ST-2096 (B) analyzed at the National Reference Center for Carbapenem-Resistant Enterobacterales, France 2013–2021.The phylogenetic trees were built with an SNP analysis approach. Scale bars under trees indicate the number of SNPs per position of common sequences. OXA, oxacillinase; SNP, single nucleotide polymorphism; ST, sequence type.
Figure 3
Figure 3
Global characterization (sequence type, year of isolation, β-lactamase content) of nonduplicate 95 OXA-232–producing Klebsiella pneumoniae analyzed at the National Reference Center for Carbapenem-Resistant Enterobacterales, France, 2013–2021. Scale bar indicates the number of SNP per position of common sequences. CMY-6, variant of C. freundii intrinsic cephalosporinase; CTX-M, cefotaximase–Munich extended-spectrum β-lactamase; OXA, oxacillinase; NDM, New Delhi metallo-β-lactamase; ST, sequence type, TEM, Temoniera β-lactamase.
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