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Review
. 2021 Mar 15;93(3):343-347.
doi: 10.26442/00403660.2021.03.200662.

[COVID-19 and the small intestine]

[Article in Russian]
Affiliations
Review

[COVID-19 and the small intestine]

[Article in Russian]
S D Bakharev et al. Ter Arkh. .

Abstract

The SARS-CoV-2 virus enters the body through the angiotensin-converting enzyme 2 (ACE-2), which is the entry point of the virus into the cell. The most dense fabric of ACE-2 is the lungs. The small intestine also contains large amounts of ACE-2 in the enterocyte membrane and is often involved in this process. Intestinal symptoms can appear at different stages of the disease. The review describes the mechanisms of interaction of SARS-CoV-2 with enterocytes, the fecal-oral route of infection, diagnosis and treatment of COVID-19 with intestinal symptoms.

Вирус SARS-CoV-2 проникает в организм через рецептор ангиотензинпревращающего фермента 2 (АПФ-2). Самой насыщенной АПФ-2-рецепторами тканью является легочная. Тонкая кишка также содержит большое количество АПФ-2-рецепторов в мембране энтероцита и часто вовлекается в процесс. Кишечные симптомы могут появляться на разных стадиях болезни. В обзоре описываются механизмы взаимодействия SARS-CoV-2 с энтероцитами, фекально-оральный путь заражения, диагностика и лечение COVID-19 c кишечной симптоматикой.

Keywords: COVID-19; angiotensin converting enzyme-2; colitis; enteral/parenteral nutrition; enteritis; enterocyte; oral-fecal route of infection; probiotics; small intestine.

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