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. 2022 Oct 24:55:e01062022.
doi: 10.1590/0037-8682-0106-2022. eCollection 2022.

Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence

Maria da Penha Gomes Gouvea  1 , Isac Ribeiro Moulaz  2 , Thayná Martins Gouveia  2 , Karen Evelin Monlevade Lança  2 , Bárbara Sthefany de Paula Lacerda  2 , Beatriz Paoli Thompson  2 , Jéssica Polese  3 , Marina Deorce de Lima  2 , Rodrigo Ribeiro-Rodrigues  4   5 , José Geraldo Mill  6 , Valéria Valim  7
Affiliations

Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence

Maria da Penha Gomes Gouvea et al. Rev Soc Bras Med Trop. .

Abstract

Background: This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence.

Methods: The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucleocapsid (anti-N) IgM and IgG for SARS-CoV-2 was evaluated. IgG antibodies to the SARS-CoV-2 spike receptor-binding domain were used to confirm non-seroconversion in all negative anti-N.

Results: Four recurrent cases displayed mild symptoms and were non-seroconverted until the recurrence of symptoms.

Conclusions: Undetectable anti-nucleocapsid IgM and IgG levels may be correlated with symptomatic COVID-19 recurrence.

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Conflict of interest statement

Conflict of Interest: The authors declare that there is no conflict of Interest.

Figures

FIGURE 1:
FIGURE 1:. IgG and IgM immunoreactivity profiles after the first and second RT-PCR positive tests. IgG values ≥ 1.4 and IgM values ≥ 1 were defined as seroconverted.
FIGURE 2:
FIGURE 2:. Kaplan-Meier curves - Comparison between seroconverted (group A) and non-seroconverted (group B). The vertical ticks represent censored observations.
See this image and copyright information in PMC

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