Practical Guide to Design Choice of Randomized Clinical Trials in Surgery

Marcel G W Dijkgraaf^{1

2}, Jason Haukoos^{3

4

5}, Kamal M F Itani^{6

7

8}

Affiliations

¹ Epidemiology and Data Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
² Methodology, Amsterdam Public Health, Amsterdam, the Netherlands.
³ Department of Emergency Medicine, Denver Health Medical Center, University of Colorado School of Medicine, Denver.
⁴ Department of Epidemiology, Colorado School of Public Health, Aurora.
⁵ Statistical Editor, JAMA Surgery.
⁶ Department of Surgery, Veterans Affairs Boston Health Care System, Boston, Massachusetts.
⁷ Department of Surgery, Boston Medical Center, Boston University, Boston, Massachusetts.
⁸ Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Comment

Marcel G W Dijkgraaf et al. JAMA Surg. 2022.

. 2022 Dec 1;157(12):1154-1155.

doi: 10.1001/jamasurg.2022.4889.

Marcel G W Dijkgraaf^{1

2}, Jason Haukoos^{3

4

5}, Kamal M F Itani^{6

7

8}

¹ Epidemiology and Data Science, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
² Methodology, Amsterdam Public Health, Amsterdam, the Netherlands.
³ Department of Emergency Medicine, Denver Health Medical Center, University of Colorado School of Medicine, Denver.
⁴ Department of Epidemiology, Colorado School of Public Health, Aurora.
⁵ Statistical Editor, JAMA Surgery.
⁶ Department of Surgery, Veterans Affairs Boston Health Care System, Boston, Massachusetts.
⁷ Department of Surgery, Boston Medical Center, Boston University, Boston, Massachusetts.
⁸ Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

No abstract available

Plain language summary

This Guide to Statistics and Methods provides an overview of the strengths and weaknesses of several randomized clinical trial design options.

Clinical Trials Design, Scientific Rigor, and Higher-Level Evidence in Surgery.
Itani KMF, Kibbe MR. Itani KMF, et al. JAMA Surg. 2022 Dec 1;157(12):1078-1079. doi: 10.1001/jamasurg.2022.4880. JAMA Surg. 2022. PMID: 36287572 No abstract available.